Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

DIRAS3 (O95661) - Overview - Molecular Target Synopsis

Protein


DIRAS3, GTP-binding protein Di-Ras3
UniProt O95661

Also Known as DIRA3_HUMAN, DIRAS3, ARHI, NOEY2, RHOI

Isoforms / Transcripts (Protein Coding)


Protein Length Ensembl Gene Ensembl Transcript Ensembl Protein Uniprot Isoform
229O95661-1

Sub-cellular localization


UniProt: DIRAS3 is active in the following subcellular-locations: cell membrane.
GO terms: DIRAS3 is active in the following subcellular-locations: plasma membrane.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project DIRAS3 has gain in 3 cell-lines, loss in 2 cell-lines and no signal in 1000 cell-lines. (see details)

Gene Expression


In NCI60, the highest expressing cell lines are: EKVX, U251, K_562

In Array Express (RNA-seq of 675 commonly used human cancer cell lines), the highest expressing cell lines are: KP4, A172, RERF-LC-MS

In Array Express (RNA-seq of long poly adenylated RNA and long non poly adenylated RNA from ENCODE cell lines), the highest expressing cell lines are: IMR-90, AG445, HSMM

(see details)

3D Structures


At greater than 35% identity similarity to DIRAS3 there are:
38 structures (66 chains) solved
30 are solved in complex with at least one small molecule ligand



(see details)
Molecular Target 3D Synopsis

Screening and Chemistry


DIRAS3 has been screened with compounds ( bioactivities). (see details)