Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

ADCY5 (O95622) - Overview - Molecular Target Synopsis

Protein


ADCY5, Adenylate cyclase type 5
Enzyme Classification 4.6.1.1
UniProt O95622

Also Known as ADCY5_HUMAN, ADCY5

Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling (PubMed:15385642, PubMed:26206488, PubMed:24700542). Mediates signaling downstream of ADRB1 (PubMed:24700542). Regulates the increase of free cytosolic Ca(2+) in response to increased blood glucose levels and contributes to the regulation of Ca(2+)-dependent insulin secretion (PubMed:24740569). Interacts with GNAS, GNB1 and GNG2 (PubMed:26206488). Part of a complex containing AKAP5, ADCY6, PDE4C and PKD2 (By similarity). Interacts with RAF1 (PubMed:15385642).

Isoforms / Transcripts (Protein Coding)


Sub-cellular localization


UniProt: ADCY5 is active in the following subcellular-locations: cell membrane, cell projection, cilium.
GO terms: ADCY5 is active in the following subcellular-locations: cilium, integral component of membrane, integral component of plasma membrane, intermediate filament cytoskeleton, plasma membrane.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project ADCY5 has gain in 2 cell-lines, loss in 1 cell-lines and no signal in 1002 cell-lines. (see details)

Gene Expression


In NCI60, the highest expressing cell lines are: RXF_393, HCT_116, SF_295

In Array Express (RNA-seq of 675 commonly used human cancer cell lines), the highest expressing cell lines are: UACC-893, DMS 53, MDA-MB-175-VII

In Array Express (RNA-seq of long poly adenylated RNA and long non poly adenylated RNA from ENCODE cell lines), the highest expressing cell lines are: SK-N-SH, NHLF, HSMM

(see details)

3D Structures


At greater than 90% identity similarity to ADCY5 there are:
16 structures (16 chains) solved
16 are solved in complex with at least one small molecule ligand



(see details)
Molecular Target 3D Synopsis

Screening and Chemistry


ADCY5 has been screened with 136 compounds (174 bioactivities), 31 compounds have bioactivities that show binding affinity of <= 500nM (33 bioactivities). (see details)