Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

ACSL3 (O95573) - Overview - Molecular Target Synopsis

Protein


ACSL3, Long-chain-fatty-acid--CoA ligase 3
Enzyme Classification 6.2.1.3
UniProt O95573

Also Known as ACSL3_HUMAN, ACSL3, ACS3, FACL3, LACS3

Acyl-CoA synthetases (ACSL) activates long-chain fatty acids for both synthesis of cellular lipids, and degradation via beta-oxidation. ACSL3 mediates hepatic lipogenesis (By similarity). Preferentially uses myristate, laurate, arachidonate and eicosapentaenoate as substrates (By similarity). Has mainly an anabolic role in energy metabolism. Required for the incorporation of fatty acids into phosphatidylcholine, the major phospholipid located on the surface of VLDL (very low density lipoproteins).

Isoforms / Transcripts (Protein Coding)


Sub-cellular localization


UniProt: ACSL3 is active in the following subcellular-locations: endoplasmic reticulum membrane, microsome membrane, mitochondrion outer membrane, peroxisome membrane.
GO terms: ACSL3 is active in the following subcellular-locations: endoplasmic reticulum, endoplasmic reticulum membrane, Golgi apparatus, integral component of membrane, lipid droplet, membrane, mitochondrial outer membrane, perinuclear region of cytoplasm, peroxisomal membrane.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project ACSL3 has gain in 0 cell-lines, loss in 2 cell-lines and no signal in 1003 cell-lines. (see details)

Gene Expression


In NCI60, the highest expressing cell lines are: MALME_3M, SK_MEL_5, UACC_257

In Array Express (RNA-seq of 675 commonly used human cancer cell lines), the highest expressing cell lines are: SK-MEL-24, Hs 695T, SK23

In Array Express (RNA-seq of long poly adenylated RNA and long non poly adenylated RNA from ENCODE cell lines), the highest expressing cell lines are: NHLF, HSMM, HMEC

(see details)


Screening and Chemistry


ACSL3 has been screened with compounds ( bioactivities). (see details)