Molecular Target Synopsis
Domains and Structures
Drugs and Clinical Candidates
Ligand Efficiency Plot
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
Germline Genetics

SLC2A10 (O95528) - Overview - Molecular Target Synopsis


SLC2A10, Solute carrier family 2, facilitated glucose transporter member 10
UniProt O95528

Also Known as GTR10_HUMAN, SLC2A10, GLUT10

Facilitative glucose transporter.

Isoforms / Transcripts (Protein Coding)

Protein Length Ensembl Gene Ensembl Transcript Ensembl Protein Uniprot Isoform

Sub-cellular localization

UniProt: SLC2A10 is active in the following subcellular-locations: cytoplasm, endomembrane system, perinuclear region.
GO terms: SLC2A10 is active in the following subcellular-locations: endomembrane system, integral component of membrane, integral component of plasma membrane, perinuclear region of cytoplasm, plasma membrane.

GO terms

Gene Copy Number Variation

In COSMIC - Cell Lines Project SLC2A10 has gain in 12 cell-lines, loss in 0 cell-lines and no signal in 993 cell-lines. (see details)

Gene Expression

In NCI60, the highest expressing cell lines are: SNB_75, SF_539, HS578T

In Array Express (RNA-seq of 675 commonly used human cancer cell lines), the highest expressing cell lines are: MFM-223, MDA-MB-361, HCC2218

In Array Express (RNA-seq of long poly adenylated RNA and long non poly adenylated RNA from ENCODE cell lines), the highest expressing cell lines are: NHLF, BJ, SK-N-SH

(see details)

3D Structures

At greater than 35% identity similarity to SLC2A10 there are:
7 structures (10 chains) solved
3 are solved in complex with at least one small molecule ligand
1 are solved with an approved drug

SLC2A10 is solved in complex with the approved drug(s):


(see details)
Molecular Target 3D Synopsis