Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

SLC2A10 (O95528) - Overview - Molecular Target Synopsis

Protein


SLC2A10, Solute carrier family 2, facilitated glucose transporter member 10
UniProt O95528

Also Known as GTR10_HUMAN, SLC2A10, GLUT10

Facilitative glucose transporter.

Isoforms / Transcripts (Protein Coding)


Protein Length Ensembl Gene Ensembl Transcript Ensembl Protein Uniprot Isoform
541ENSG00000197496ENST00000359271ENSP00000352216O95528-1

Sub-cellular localization


UniProt: SLC2A10 is active in the following subcellular-locations: cytoplasm, endomembrane system, perinuclear region.
GO terms: SLC2A10 is active in the following subcellular-locations: endomembrane system, integral component of membrane, integral component of plasma membrane, perinuclear region of cytoplasm, plasma membrane.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project SLC2A10 has gain in 12 cell-lines, loss in 0 cell-lines and no signal in 993 cell-lines. (see details)

Gene Expression


In NCI60, the highest expressing cell lines are: SNB_75, SF_539, HS578T

In Array Express (RNA-seq of 675 commonly used human cancer cell lines), the highest expressing cell lines are: MFM-223, MDA-MB-361, HCC2218

In Array Express (RNA-seq of long poly adenylated RNA and long non poly adenylated RNA from ENCODE cell lines), the highest expressing cell lines are: NHLF, BJ, SK-N-SH

(see details)

3D Structures


At greater than 35% identity similarity to SLC2A10 there are:
7 structures (10 chains) solved
3 are solved in complex with at least one small molecule ligand
1 are solved with an approved drug

SLC2A10 is solved in complex with the approved drug(s):

BGC/DEXTROSE (4GBZ_A).

(see details)
Molecular Target 3D Synopsis