Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

TGDS (O95455) - Overview - Molecular Target Synopsis

Protein


TGDS, dTDP-D-glucose 4,6-dehydratase
Enzyme Classification 4.2.1.46
UniProt O95455

Also Known as TGDS_HUMAN, TGDS

Isoforms / Transcripts (Protein Coding)


Protein Length Ensembl Gene Ensembl Transcript Ensembl Protein Uniprot Isoform
350ENSG00000088451ENST00000261296ENSP00000261296O95455-1

Gene Copy Number Variation


In COSMIC - Cell Lines Project TGDS has gain in 8 cell-lines, loss in 8 cell-lines and no signal in 989 cell-lines. (see details)

Gene Expression


In NCI60, the highest expressing cell lines are: HL_60, SW_620, COLO205

In Array Express (RNA-seq of 675 commonly used human cancer cell lines), the highest expressing cell lines are: RL, COLO 857, MKN-45

In Array Express (RNA-seq of long poly adenylated RNA and long non poly adenylated RNA from ENCODE cell lines), the highest expressing cell lines are: NHLF, AG445, MCF-7

(see details)

3D Structures


At greater than 35% identity similarity to TGDS there are:
4 structures (8 chains) solved
4 are solved in complex with at least one small molecule ligand
1 are solved with an approved drug

TGDS is solved in complex with the approved drug(s):

SUC/SUCROSE (6BI4_C, 6BI4_D).

(see details)
Molecular Target 3D Synopsis