Molecular Target Synopsis
Domains and Structures
Drugs and Clinical Candidates
Ligand Efficiency Plot
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
Germline Genetics

TGDS (O95455) - Overview - Molecular Target Synopsis


TGDS, dTDP-D-glucose 4,6-dehydratase
Enzyme Classification
UniProt O95455

Also Known as TGDS_HUMAN, TGDS

Isoforms / Transcripts (Protein Coding)

Protein Length Ensembl Gene Ensembl Transcript Ensembl Protein Uniprot Isoform

Gene Copy Number Variation

In COSMIC - Cell Lines Project TGDS has gain in 8 cell-lines, loss in 8 cell-lines and no signal in 989 cell-lines. (see details)

Gene Expression

In NCI60, the highest expressing cell lines are: HL_60, SW_620, COLO205

In Array Express (RNA-seq of 675 commonly used human cancer cell lines), the highest expressing cell lines are: RL, COLO 857, MKN-45

In Array Express (RNA-seq of long poly adenylated RNA and long non poly adenylated RNA from ENCODE cell lines), the highest expressing cell lines are: NHLF, AG445, MCF-7

(see details)

3D Structures

At greater than 35% identity similarity to TGDS there are:
4 structures (8 chains) solved
4 are solved in complex with at least one small molecule ligand
1 are solved with an approved drug

TGDS is solved in complex with the approved drug(s):


(see details)
Molecular Target 3D Synopsis