AHSA1 (O95433) - Overview - Molecular Target Synopsis
AHSA1, Activator of 90 kDa heat shock protein ATPase homolog 1
Also Known as AHSA1_HUMAN, AHSA1, C14orf3
Acts as a co-chaperone of HSP90AA1 (PubMed:29127155). Activates the ATPase activity of HSP90AA1 leading to increase in its chaperone activity (PubMed:29127155). Competes with the inhibitory co-chaperone FNIP1 for binding to HSP90AA1, thereby providing a reciprocal regulatory mechanism for chaperoning of client proteins (PubMed:27353360). Competes with the inhibitory co-chaperone TSC1 for binding to HSP90AA1, thereby providing a reciprocal regulatory mechanism for chaperoning of client proteins (PubMed:29127155). Interacts with HSPCA/HSP90 (PubMed:12504007, PubMed:12604615). Interacts (phosphorylated on Tyr-223) with HSP90AA1; the interaction activates HSP90AA1 ATPase activity (PubMed:27353360, PubMed:29127155). Interacts with HSP90AB1 (By similarity). Interacts with GCH1 (PubMed:16696853). Interacts with SRPK1 (PubMed:19240134). Interacts with FLCN (PubMed:27353360).
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UniProt: AHSA1 is active in the following subcellular-locations: cytoplasm, cytosol, endoplasmic reticulum.
GO terms: AHSA1 is active in the following subcellular-locations: cytosol, endoplasmic reticulum, extracellular exosome.