Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

MAP3K6 (O95382) - Overview - Molecular Target Synopsis

Protein


MAP3K6, Mitogen-activated protein kinase kinase kinase 6
Enzyme Classification 2.7.11.25
UniProt O95382

Also Known as M3K6_HUMAN, MAP3K6, ASK2, MAPKKK6, MEKK6

Component of a protein kinase signal transduction cascade. Activates the JNK, but not ERK or p38 kinase pathways. Binds both upstream activators and downstream substrates in multimolecular complexes.

Isoforms / Transcripts (Protein Coding)


Gene Copy Number Variation


In COSMIC - Cell Lines Project MAP3K6 has gain in 1 cell-lines, loss in 1 cell-lines and no signal in 1002 cell-lines. (see details)

Gene Expression


In NCI60, the highest expressing cell lines are: SK_MEL_28, UACC_257, SK_OV_3

In Array Express (RNA-seq of 675 commonly used human cancer cell lines), the highest expressing cell lines are: DMS 79, COLO 699, BICR 31

In Array Express (RNA-seq of long poly adenylated RNA and long non poly adenylated RNA from ENCODE cell lines), the highest expressing cell lines are: SK-N-SH, K562, HMEC

(see details)

RNA Interference


MAP3K6 was reported in the following RNAI studies:

Cell - Large Scale Profiling of Kinase Dependencies in Cancer Cell Lines, the highest RNAi cell lines are: H1650, OAW42. (see details)

3D Structures


At greater than 75% identity similarity to MAP3K6 there are:
18 structures (40 chains) solved
18 are solved in complex with at least one small molecule ligand



(see details)
Molecular Target 3D Synopsis

Screening and Chemistry


MAP3K6 has been screened with 89 compounds (95 bioactivities), 2 compounds have bioactivities that show binding affinity of <= 500nM (3 bioactivities). (see details)