Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

SMC2 (O95347) - Overview - Molecular Target Synopsis

Protein


SMC2, Structural maintenance of chromosomes protein 2
UniProt O95347

Also Known as SMC2_HUMAN, SMC2, CAPE, SMC2L1

Central component of the condensin complex, a complex required for conversion of interphase chromatin into mitotic-like condense chromosomes. The condensin complex probably introduces positive supercoils into relaxed DNA in the presence of type I topoisomerases and converts nicked DNA into positive knotted forms in the presence of type II topoisomerases. Forms a heterodimer with SMC4. Component of the condensin complex, which contains the SMC2 and SMC4 heterodimer, and three non SMC subunits that probably regulate the complex: BRRN1/CAPH, CNAP1/CAPD2 and CAPG. Interacts with BRD4 (isoform B), leading to insulate chromatin from DNA damage response pathway.

4U4P
CRYSTAL STRUCTURE OF THE HUMAN CONDENSIN SMC HINGE DOMAIN HETERODIMER WITH SHORT COILED COILS
RCSB/PDB
Inspect Structure
See all 3D Structures for SMC2

Isoforms / Transcripts (Protein Coding)


Sub-cellular localization


UniProt: SMC2 is active in the following subcellular-locations: chromosome, cytoplasm, nucleus.
GO terms: SMC2 is active in the following subcellular-locations: condensed chromosome, condensin complex, cytoplasm, cytosol, extracellular exosome, nuclear chromosome, nucleolus, nucleoplasm, nucleus.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project SMC2 has gain in 1 cell-lines, loss in 1 cell-lines and no signal in 1003 cell-lines. (see details)

Gene Expression


In NCI60, the highest expressing cell lines are: SN12C, CCRF_CEM, MDA_MB_231

In Array Express (RNA-seq of 675 commonly used human cancer cell lines), the highest expressing cell lines are: COR-L88, NCI-H510A, NCI-H209

In Array Express (RNA-seq of long poly adenylated RNA and long non poly adenylated RNA from ENCODE cell lines), the highest expressing cell lines are: MCF-7, HMEC, NHLF

(see details)

3D Structures


For SMC2 there are:
1 structures (1 chains) solved
0 are solved in complex with at least one small molecule ligand



(see details)
Molecular Target 3D Synopsis