Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

ABCB11 (O95342) - Overview - Molecular Target Synopsis

Protein


ABCB11, Bile salt export pump
UniProt O95342

Also Known as ABCBB_HUMAN, ABCB11, BSEP

Involved in the ATP-dependent secretion of bile salts into the canaliculus of hepatocytes. Interacts with HAX1.

Isoforms / Transcripts (Protein Coding)


Protein Length Ensembl Gene Ensembl Transcript Ensembl Protein Uniprot Isoform
1321ENSG00000073734ENST00000263817ENSP00000263817O95342-1
72ENSG00000073734ENST00000439188ENSP00000416058

Sub-cellular localization


UniProt: ABCB11 is active in the following subcellular-locations: membrane.
GO terms: ABCB11 is active in the following subcellular-locations: extracellular exosome, integral component of plasma membrane, membrane, plasma membrane.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project ABCB11 has gain in 2 cell-lines, loss in 2 cell-lines and no signal in 1001 cell-lines. (see details)

Gene Expression


In NCI60, the highest expressing cell lines are: MCF7, HL_60, RPMI_8226

In Array Express (RNA-seq of 675 commonly used human cancer cell lines), the highest expressing cell lines are: Hs 746T, NCI-H209, LN-18

In Array Express (RNA-seq of long poly adenylated RNA and long non poly adenylated RNA from ENCODE cell lines), the highest expressing cell lines are: SK-N-SH, NHLF, HSMM

(see details)

3D Structures


At greater than 50% identity similarity to ABCB11 there are:
28 structures (39 chains) solved
13 are solved in complex with at least one small molecule ligand
2 are solved with an approved drug

ABCB11 is solved in complex with the approved drug(s):

CLR/CHOLESTEROL (6QEE_A, 6QEX_A),
TA1/PACLITAXEL (6QEX_A).

(see details)
Molecular Target 3D Synopsis

Screening and Chemistry


ABCB11 has been screened with 1196 compounds (1733 bioactivities), 5 compounds have bioactivities that show binding affinity of <= 500nM (11 bioactivities). (see details)