Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

ABCC6 (O95255) - Overview - Molecular Target Synopsis

Protein


ABCC6, Multidrug resistance-associated protein 6
UniProt O95255

Also Known as MRP6_HUMAN, ABCC6, ARA, MRP6

Isoform 1: May participate directly in the active transport of drugs into subcellular organelles or influence drug distribution indirectly. Transports glutathione conjugates as leukotriene-c4 (LTC4) and N-ethylmaleimide S-glutathione (NEM-GS)., Isoform 2: Inhibits TNF-alpha-mediated apoptosis through blocking one or more caspases.

6BZR
HUMAN ABCC6 NBD2 IN ADP-BOUND STATE
RCSB/PDB
Inspect Structure
See all 3D Structures for ABCC6

Isoforms / Transcripts (Protein Coding)


Sub-cellular localization


UniProt: ABCC6 is active in the following subcellular-locations: basolateral cell membrane, endoplasmic reticulum membrane.
GO terms: ABCC6 is active in the following subcellular-locations: apical plasma membrane, basolateral plasma membrane, endoplasmic reticulum membrane, integral component of membrane, lateral plasma membrane, membrane, nucleus, plasma membrane, vacuolar membrane.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project ABCC6 has gain in 1 cell-lines, loss in 0 cell-lines and no signal in 1004 cell-lines. (see details)

Gene Expression


In NCI60, the highest expressing cell lines are: T47D, MCF7, HL_60

In Array Express (RNA-seq of 675 commonly used human cancer cell lines), the highest expressing cell lines are: HuH-7, Hep G2, C3A

In Array Express (RNA-seq of long poly adenylated RNA and long non poly adenylated RNA from ENCODE cell lines), the highest expressing cell lines are: SK-N-SH, NHLF, HSMM

(see details)

3D Structures


For ABCC6 there are:
2 structures (3 chains) solved
1 are solved in complex with at least one small molecule ligand



(see details)
Molecular Target 3D Synopsis

Screening and Chemistry


ABCC6 has been screened with 13 compounds (17 bioactivities). (see details)