Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

LUC7L3 (O95232) - Overview - Molecular Target Synopsis

Protein


LUC7L3, Luc7-like protein 3
UniProt O95232

Also Known as LC7L3_HUMAN, LUC7L3, CREAP1, CROP, O48

Binds cAMP regulatory element DNA sequence. May play a role in RNA splicing. May interact with SFRS1 and form homodimers (PubMed:12565863). Interacts with JMJD6 (PubMed:19574390). Interacts with RBM25 (PubMed:18663000). Interacts with RSRC1 (via Arg/Ser-rich domain) (PubMed:15798186). Interacts with RRP1B (PubMed:23604122).

Isoforms / Transcripts (Protein Coding)


Sub-cellular localization


UniProt: LUC7L3 is active in the following subcellular-locations: nucleus speckle.
GO terms: LUC7L3 is active in the following subcellular-locations: nuclear speck, nucleoplasm, nucleus, U1 snRNP, U2-type prespliceosome.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project LUC7L3 has gain in 6 cell-lines, loss in 0 cell-lines and no signal in 999 cell-lines. (see details)

Gene Expression


In NCI60, the highest expressing cell lines are:

In Array Express (RNA-seq of 675 commonly used human cancer cell lines), the highest expressing cell lines are: NCI-H1882, NCI-H847, COR-L47

In Array Express (RNA-seq of long poly adenylated RNA and long non poly adenylated RNA from ENCODE cell lines), the highest expressing cell lines are: SK-N-SH, K562, MCF-7

(see details)