Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

TSPOAP1 (O95153) - Overview - Molecular Target Synopsis

Protein


TSPOAP1, Peripheral-type benzodiazepine receptor-associated protein 1
UniProt O95153

Also Known as RIMB1_HUMAN, TSPOAP1, BZRAP1, KIAA0612, RBP1, RIMBP1

Interacts with RIMS1 and RIMS2 (By similarity). Interacts with TSPO.

Isoforms / Transcripts (Protein Coding)


Sub-cellular localization


UniProt: TSPOAP1 is active in the following subcellular-locations: cytoplasm, mitochondrion.
GO terms: TSPOAP1 is active in the following subcellular-locations: calyx of Held, cytoplasm, cytosol, glutamatergic synapse, mitochondrion.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project TSPOAP1 has gain in 6 cell-lines, loss in 1 cell-lines and no signal in 998 cell-lines. (see details)

Gene Expression


In NCI60, the highest expressing cell lines are:

In Array Express (RNA-seq of 675 commonly used human cancer cell lines), the highest expressing cell lines are:

In Array Express (RNA-seq of long poly adenylated RNA and long non poly adenylated RNA from ENCODE cell lines), the highest expressing cell lines are:

(see details)

3D Structures


At greater than 50% identity similarity to TSPOAP1 there are:
6 structures (26 chains) solved
0 are solved in complex with at least one small molecule ligand



(see details)
Molecular Target 3D Synopsis