Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

DIRAS1 (O95057) - Overview - Molecular Target Synopsis

Protein


DIRAS1, GTP-binding protein Di-Ras1
UniProt O95057

Also Known as DIRA1_HUMAN, DIRAS1, GBTS1, RIG

Displays low GTPase activity and exists predominantly in the GTP-bound form.

2GF0
THE CRYSTAL STRUCTURE OF THE HUMAN DIRAS1 GTPASE IN THE INACTIVE GDP BOUND STATE
RCSB/PDB
Inspect Structure
See all 3D Structures for DIRAS1

Isoforms / Transcripts (Protein Coding)


Sub-cellular localization


UniProt: DIRAS1 is active in the following subcellular-locations: cell membrane.
GO terms: DIRAS1 is active in the following subcellular-locations: plasma membrane.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project DIRAS1 has gain in 0 cell-lines, loss in 4 cell-lines and no signal in 1001 cell-lines. (see details)

Gene Expression


In NCI60, the highest expressing cell lines are: UACC_62, HCT_116, SK_MEL_5

In Array Express (RNA-seq of 675 commonly used human cancer cell lines), the highest expressing cell lines are: HCC12, NCI-H1155, SK23

In Array Express (RNA-seq of long poly adenylated RNA and long non poly adenylated RNA from ENCODE cell lines), the highest expressing cell lines are: BJ, AG445, HMEC

(see details)

3D Structures


For DIRAS1 there are:
1 structures (4 chains) solved
1 are solved in complex with at least one small molecule ligand



(see details)
Molecular Target 3D Synopsis

Screening and Chemistry


DIRAS1 has been screened with compounds ( bioactivities). (see details)