Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

INMT (O95050) - Overview - Molecular Target Synopsis

Protein


INMT, Indolethylamine N-methyltransferase
Enzyme Classification 2.1.1.49
UniProt O95050

Also Known as INMT_HUMAN, INMT

Functions as thioether S-methyltransferase and is active with a variety of thioethers and the corresponding selenium and tellurium compounds, including 3-methylthiopropionaldehyde, dimethyl selenide, dimethyl telluride, 2-methylthioethylamine, 2-methylthioethanol, methyl-n-propyl sulfide and diethyl sulfide. Plays an important role in the detoxification of selenium compounds (By similarity). Catalyzes the N-methylation of tryptamine and structurally related compounds. Monomer.

2A14
CRYSTAL STRUCTURE OF HUMAN INDOLETHYLAMINE N- METHYLTRANSFERASE WITH SAH
RCSB/PDB
Inspect Structure
See all 3D Structures for INMT

Isoforms / Transcripts (Protein Coding)


Protein Length Ensembl Gene Ensembl Transcript Ensembl Protein Uniprot Isoform
263ENSG00000241644ENST00000013222ENSP00000013222O95050-1
262ENSG00000241644ENST00000409539ENSP00000386961O95050-2

Sub-cellular localization


UniProt: INMT is active in the following subcellular-locations: cytoplasm.
GO terms: INMT is active in the following subcellular-locations: cytoplasm, cytosol.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project INMT has gain in 6 cell-lines, loss in 1 cell-lines and no signal in 998 cell-lines. (see details)

Gene Expression


In NCI60, the highest expressing cell lines are: SK_MEL_2, RPMI_8226, HS578T

In Array Express (RNA-seq of 675 commonly used human cancer cell lines), the highest expressing cell lines are: Hs 675.T, Hs 255.T, Hs 895.T

In Array Express (RNA-seq of long poly adenylated RNA and long non poly adenylated RNA from ENCODE cell lines), the highest expressing cell lines are: NHLF, SK-N-SH, HSMM

(see details)

3D Structures


For INMT there are:
1 structures (1 chains) solved
1 are solved in complex with at least one small molecule ligand



(see details)
Molecular Target 3D Synopsis

Screening and Chemistry


INMT has been screened with 61 compounds (96 bioactivities). (see details)