Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

SLCO2B1 (O94956) - Overview - Molecular Target Synopsis

Protein


SLCO2B1, Solute carrier organic anion transporter family member 2B1
UniProt O94956

Also Known as SO2B1_HUMAN, SLCO2B1, KIAA0880, OATP2B1, OATPB, SLC21A9

Mediates the Na(+)-independent transport of organic anions such as taurocholate, the prostaglandins PGD2, PGE1, PGE2, leukotriene C4, thromboxane B2 and iloprost.

Isoforms / Transcripts (Protein Coding)


Sub-cellular localization


UniProt: SLCO2B1 is active in the following subcellular-locations: cell membrane.
GO terms: SLCO2B1 is active in the following subcellular-locations: integral component of plasma membrane, plasma membrane.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project SLCO2B1 has gain in 9 cell-lines, loss in 0 cell-lines and no signal in 996 cell-lines. (see details)

Gene Expression


In NCI60, the highest expressing cell lines are: COLO205, DU_145, RXF_393

In Array Express (RNA-seq of 675 commonly used human cancer cell lines), the highest expressing cell lines are: OCUM-1, C2BBe1, RERF-GC-1B

In Array Express (RNA-seq of long poly adenylated RNA and long non poly adenylated RNA from ENCODE cell lines), the highest expressing cell lines are: SK-N-SH, NHLF, HSMM

(see details)


Screening and Chemistry


SLCO2B1 has been screened with 268 compounds (428 bioactivities), 1 compounds have bioactivities that show binding affinity of <= 500nM (2 bioactivities). (see details)