Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

KDM4B (O94953) - Overview - Molecular Target Synopsis

Protein


KDM4B, Lysine-specific demethylase 4B
Enzyme Classification 1.14.11.-
UniProt O94953

Also Known as KDM4B_HUMAN, KDM4B, JHDM3B, JMJD2B, KIAA0876

Histone demethylase that specifically demethylates 'Lys-9' of histone H3, thereby playing a role in histone code. Does not demethylate histone H3 'Lys-4', H3 'Lys-27', H3 'Lys-36' nor H4 'Lys-20'. Only able to demethylate trimethylated H3 'Lys-9', with a weaker activity than KDM4A, KDM4C and KDM4D. Demethylation of Lys residue generates formaldehyde and succinate.

4UC4
CRYSTAL STRUCTURE OF HYBRID TUDOR DOMAIN OF HUMAN LYSINE DEMETHYLASE KDM4B
RCSB/PDB
Inspect Structure
See all 3D Structures for KDM4B

Isoforms / Transcripts (Protein Coding)


Sub-cellular localization


UniProt: KDM4B is active in the following subcellular-locations: nucleus.
GO terms: KDM4B is active in the following subcellular-locations: histone methyltransferase complex, nucleoplasm, nucleus.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project KDM4B has gain in 0 cell-lines, loss in 2 cell-lines and no signal in 1003 cell-lines. (see details)

Gene Expression


In NCI60, the highest expressing cell lines are:

In Array Express (RNA-seq of 675 commonly used human cancer cell lines), the highest expressing cell lines are: MDA-MB-134-VI, NCI-H209, NCI-H187

In Array Express (RNA-seq of long poly adenylated RNA and long non poly adenylated RNA from ENCODE cell lines), the highest expressing cell lines are: SK-N-SH, CD20-positive B cell, NHLF

(see details)

3D Structures


For KDM4B there are:
2 structures (3 chains) solved
1 are solved in complex with at least one small molecule ligand



(see details)
Molecular Target 3D Synopsis

Screening and Chemistry


KDM4B has been screened with compounds ( bioactivities). (see details)