Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

ABCA8 (O94911) - Overview - Molecular Target Synopsis

Protein


ABCA8, ATP-binding cassette sub-family A member 8
UniProt O94911

Also Known as ABCA8_HUMAN, ABCA8, KIAA0822

ATP-dependent lipophilic drug transporter.

Isoforms / Transcripts (Protein Coding)


Sub-cellular localization


UniProt: ABCA8 is active in the following subcellular-locations: cell membrane.
GO terms: ABCA8 is active in the following subcellular-locations: integral component of membrane, intracellular membrane-bounded organelle, plasma membrane.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project ABCA8 has gain in 5 cell-lines, loss in 0 cell-lines and no signal in 1000 cell-lines. (see details)

Gene Expression


In NCI60, the highest expressing cell lines are: SK_MEL_5, NCI_H460, UACC_62

In Array Express (RNA-seq of 675 commonly used human cancer cell lines), the highest expressing cell lines are: NCI-H460, NCI-H2461, Hs 746T

In Array Express (RNA-seq of long poly adenylated RNA and long non poly adenylated RNA from ENCODE cell lines), the highest expressing cell lines are: SK-N-SH, HSMM, HMEC

(see details)

3D Structures


At greater than 35% identity similarity to ABCA8 there are:
2 structures (4 chains) solved
2 are solved in complex with at least one small molecule ligand



(see details)
Molecular Target 3D Synopsis

Screening and Chemistry


ABCA8 has been screened with compounds ( bioactivities). (see details)