Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

RHOBTB1 (O94844) - Overview - Molecular Target Synopsis

Protein


RHOBTB1, Rho-related BTB domain-containing protein 1
UniProt O94844

Also Known as RHBT1_HUMAN, RHOBTB1, KIAA0740

Isoforms / Transcripts (Protein Coding)


Protein Length Ensembl Gene Ensembl Transcript Ensembl Protein Uniprot Isoform
696ENSG00000072422ENST00000337910, ENST00000357917ENSP00000338671, ENSP00000350595O94844-1

Sub-cellular localization


GO terms: RHOBTB1 is active in the following subcellular-locations: cell projection, cytoplasm, cytosol, plasma membrane.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project RHOBTB1 has gain in 6 cell-lines, loss in 0 cell-lines and no signal in 999 cell-lines. (see details)

Gene Expression


In NCI60, the highest expressing cell lines are: A498, EKVX, RXF_393

In Array Express (RNA-seq of 675 commonly used human cancer cell lines), the highest expressing cell lines are: C3A, Hep G2, NCI-H1568

In Array Express (RNA-seq of long poly adenylated RNA and long non poly adenylated RNA from ENCODE cell lines), the highest expressing cell lines are: HSMM, SK-N-SH, NHLF

(see details)

3D Structures


At greater than 35% identity similarity to RHOBTB1 there are:
144 structures (244 chains) solved
112 are solved in complex with at least one small molecule ligand
5 are solved with an approved drug

RHOBTB1 is solved in complex with the approved drug(s):

FMN/RIBOFLAVIN 5'-PHOSPHATE (2WKP_A, 2WKQ_A, 2WKR_A, 5HZH_A),
AMP/ADENOSINE PHOSPHATE (4ITR_C, 4ITR_D).

(see details)
Molecular Target 3D Synopsis

Screening and Chemistry


RHOBTB1 has been screened with compounds ( bioactivities). (see details)