Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

PRKD3 (O94806) - Overview - Molecular Target Synopsis

Protein


PRKD3, Serine/threonine-protein kinase D3
Enzyme Classification 2.7.11.13
UniProt O94806

Also Known as KPCD3_HUMAN, PRKD3, EPK2, PRKCN

Converts transient diacylglycerol (DAG) signals into prolonged physiological effects, downstream of PKC. Involved in resistance to oxidative stress.

2D9Z
SOLUTION STRUCTURE OF THE PH DOMAIN OF PROTEIN KINASE C, NU TYPE FROM HUMAN
RCSB/PDB
Inspect Structure
See all 3D Structures for PRKD3

Isoforms / Transcripts (Protein Coding)


Sub-cellular localization


UniProt: PRKD3 is active in the following subcellular-locations: cytoplasm, membrane.
GO terms: PRKD3 is active in the following subcellular-locations: cytosol, membrane, nucleoplasm.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project PRKD3 has gain in 3 cell-lines, loss in 1 cell-lines and no signal in 1001 cell-lines. (see details)

Gene Expression


In NCI60, the highest expressing cell lines are: UACC_257, SK_MEL_5, MALME_3M

In Array Express (RNA-seq of 675 commonly used human cancer cell lines), the highest expressing cell lines are: U266B1, 928 mel, 888

In Array Express (RNA-seq of long poly adenylated RNA and long non poly adenylated RNA from ENCODE cell lines), the highest expressing cell lines are: NHLF, AG445, SK-N-SH

(see details)

RNA Interference


PRKD3 was reported in the following RNAI studies:

Cell - Large Scale Profiling of Kinase Dependencies in Cancer Cell Lines, the highest RNAi cell lines are: HELA, MG63. (see details)

3D Structures


For PRKD3 there are:
1 structures (1 chains) solved
0 are solved in complex with at least one small molecule ligand



(see details)
Molecular Target 3D Synopsis

Screening and Chemistry


PRKD3 has been screened with 1004 compounds (1621 bioactivities), 96 compounds have bioactivities that show binding affinity of <= 500nM (121 bioactivities). (see details)