STK10 (O94804) - Overview - Molecular Target Synopsis
STK10, Serine/threonine-protein kinase 10
Enzyme Classification 188.8.131.52
Also Known as STK10_HUMAN, STK10, LOK
Serine/threonine-protein kinase involved in regulation of lymphocyte migration. Phosphorylates MSN, and possibly PLK1. Involved in regulation of lymphocyte migration by mediating phosphorylation of ERM proteins such as MSN. Acts as a negative regulator of MAP3K1/MEKK1. May also act as a cell cycle regulator by acting as a polo kinase kinase: mediates phosphorylation of PLK1 in vitro; however such data require additional evidences in vivo. Homodimer; homodimerization is required for activation segment autophosphorylation.
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UniProt: STK10 is active in the following subcellular-locations: cell membrane.
GO terms: STK10 is active in the following subcellular-locations: cytoplasm, extracellular exosome, plasma membrane, specific granule membrane.