Molecular Target Synopsis
Domains and Structures
Drugs and Clinical Candidates
Ligand Efficiency Plot
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
Germline Genetics

STK10 (O94804) - Overview - Molecular Target Synopsis


STK10, Serine/threonine-protein kinase 10
Enzyme Classification
UniProt O94804

Also Known as STK10_HUMAN, STK10, LOK

Serine/threonine-protein kinase involved in regulation of lymphocyte migration. Phosphorylates MSN, and possibly PLK1. Involved in regulation of lymphocyte migration by mediating phosphorylation of ERM proteins such as MSN. Acts as a negative regulator of MAP3K1/MEKK1. May also act as a cell cycle regulator by acting as a polo kinase kinase: mediates phosphorylation of PLK1 in vitro; however such data require additional evidences in vivo. Homodimer; homodimerization is required for activation segment autophosphorylation.

Isoforms / Transcripts (Protein Coding)

Protein Length Ensembl Gene Ensembl Transcript Ensembl Protein Uniprot Isoform

Sub-cellular localization

UniProt: STK10 is active in the following subcellular-locations: cell membrane.
GO terms: STK10 is active in the following subcellular-locations: cytoplasm, extracellular exosome, plasma membrane, specific granule membrane.

GO terms

Gene Copy Number Variation

In COSMIC - Cell Lines Project STK10 has gain in 2 cell-lines, loss in 4 cell-lines and no signal in 998 cell-lines. (see details)

Gene Expression

In NCI60, the highest expressing cell lines are: HL_60, SK_MEL_28, M14

In Array Express (RNA-seq of 675 commonly used human cancer cell lines), the highest expressing cell lines are: WM-115, HNT-34, HEL

In Array Express (RNA-seq of long poly adenylated RNA and long non poly adenylated RNA from ENCODE cell lines), the highest expressing cell lines are: SK-N-SH, HMEC, CD14-positive monocyte

(see details)

RNA Interference

STK10 was reported in the following RNAI studies:

Cell - Large Scale Profiling of Kinase Dependencies in Cancer Cell Lines, the highest RNAi cell lines are: PCI30, BEN. (see details)

3D Structures

There are 11 structures (18 chains) solved for STK10
11 are solved in complex with at least one small molecule ligand
2 are solved with an approved drug

STK10 is solved in complex with the approved drug(s):


(see details)
Molecular Target 3D Synopsis

Screening and Chemistry

STK10 has been screened with 774 compounds (1450 bioactivities), 35 compounds have bioactivities that show binding affinity of <= 500nM (62 bioactivities). (see details)