Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

STK17B (O94768) - Overview - Molecular Target Synopsis

Protein


STK17B, Serine/threonine-protein kinase 17B
Enzyme Classification 2.7.11.1
UniProt O94768

Also Known as ST17B_HUMAN, STK17B, DRAK2

Phosphorylates myosin light chains (By similarity). Acts as a positive regulator of apoptosis. Interacts with CHP1; the interaction induces CHP1 to translocate from the Golgi to the nucleus.

3LM5
CRYSTAL STRUCTURE OF HUMAN SERINE/THREONINE KINASE 17B (STK17B) IN COMPLEX WITH QUERCETIN
RCSB/PDB
Inspect Structure
See all 3D Structures for STK17B

Isoforms / Transcripts (Protein Coding)


Sub-cellular localization


UniProt: STK17B is active in the following subcellular-locations: cell membrane, endoplasmic reticulum-golgi intermediate compartment, nucleus.
GO terms: STK17B is active in the following subcellular-locations: actin cytoskeleton, endoplasmic reticulum-Golgi intermediate compartment, nucleus, plasma membrane.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project STK17B has gain in 1 cell-lines, loss in 1 cell-lines and no signal in 1003 cell-lines. (see details)

Gene Expression


In NCI60, the highest expressing cell lines are: SK_MEL_28, HS578T, RPMI_8226

In Array Express (RNA-seq of 675 commonly used human cancer cell lines), the highest expressing cell lines are: Daudi, SU-DHL-5, KARPAS-422

In Array Express (RNA-seq of long poly adenylated RNA and long non poly adenylated RNA from ENCODE cell lines), the highest expressing cell lines are: HSMM, NHLF, AG445

(see details)

RNA Interference


STK17B was reported in the following RNAI studies:

Cell - Large Scale Profiling of Kinase Dependencies in Cancer Cell Lines, the highest RNAi cell lines are: BXPC3, HCC1954. (see details)

3D Structures


For STK17B there are:
2 structures (2 chains) solved
2 are solved in complex with at least one small molecule ligand



(see details)
Molecular Target 3D Synopsis

Screening and Chemistry


STK17B has been screened with 230 compounds (350 bioactivities), 26 compounds have bioactivities that show binding affinity of <= 500nM (38 bioactivities). (see details)