Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

mag2 (O94468) - Overview - Molecular Target Synopsis

Protein


mag2, Probable DNA-3-methyladenine glycosylase 2
Enzyme Classification 3.2.2.21
UniProt O94468

Also Known as MAG2_SCHPO, mag2

Involved in base excision repair of methyl methanesulfonate-damaged DNA by hydrolysis of the deoxyribose N-glycosidic bond to excise 3-methyladenine or 7-methyladenine from the damaged DNA polymer formed by alkylation lesions.

4HSB
S. POMBE 3-METHYLADENINE DNA GLYCOSYLASE-LIKE PROTEIN MAG2 BOUND TO DAMAGED DNA
RCSB/PDB
Inspect Structure
See all 3D Structures for mag2

Isoforms / Transcripts (Protein Coding)


Protein Length Ensembl Gene Ensembl Transcript Ensembl Protein Uniprot Isoform
213O94468-1

Sub-cellular localization


UniProt: mag2 is active in the following subcellular-locations: nucleus.
GO terms: mag2 is active in the following subcellular-locations: nucleus, protein-DNA complex.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project mag2 has gain in 0 cell-lines, loss in 0 cell-lines and no signal in 0 cell-lines. (see details)

RNA Interference


mag2 was reported in the following RNAI studies:

Cell - Large Scale Profiling of Kinase Dependencies in Cancer Cell Lines, the highest RNAi cell lines are: . (see details)

3D Structures


For mag2 there are:
5 structures (5 chains) solved
1 are solved in complex with at least one small molecule ligand
1 are solved with an approved drug

mag2 is solved in complex with the approved drug(s):

BGC/DEXTROSE (4B21_A).

(see details)
Molecular Target 3D Synopsis