Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
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Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

los1 (O94258) - Overview - Molecular Target Synopsis

Protein


los1, Exportin-T
UniProt O94258

Also Known as XPOT_SCHPO, los1

tRNA nucleus export receptor which facilitates tRNA translocation across the nuclear pore complex. Involved in pre-tRNA splicing, probably by affecting the interaction of pre-tRNA with splicing endonuclease.

3IBV
KARYOPHERIN CYTOSOLIC STATE
RCSB/PDB
Inspect Structure
See all 3D Structures for los1

Isoforms / Transcripts (Protein Coding)


Protein Length Ensembl Gene Ensembl Transcript Ensembl Protein Uniprot Isoform
978O94258-1

Sub-cellular localization


UniProt: los1 is active in the following subcellular-locations: cytoplasm, nucleus.
GO terms: los1 is active in the following subcellular-locations: cytoplasm, cytosol, nuclear envelope, nuclear matrix, nuclear pore, nucleus.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project los1 has gain in 0 cell-lines, loss in 0 cell-lines and no signal in 0 cell-lines. (see details)

3D Structures


For los1 there are:
2 structures (4 chains) solved
0 are solved in complex with at least one small molecule ligand



(see details)
Molecular Target 3D Synopsis