Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

F2rl3 (O88634) - Overview - Molecular Target Synopsis

Protein


F2rl3, Proteinase-activated receptor 4
UniProt O88634

Also Known as PAR4_MOUSE, F2rl3, Par4

Receptor for activated thrombin or trypsin coupled to G proteins that stimulate phosphoinositide hydrolysis. May play a role in platelets activation.

2PV9
26 RESIDUE FRAGMENT OF
PROTEINASE-ACTIVATED RECEPTOR 4
IN THE STRUCTURE OF
CRYSTAL STRUCTURE OF MURINE THROMBIN IN COMPLEX WITH THE EXTRACELLULAR FRAGMENT OF MURINE PAR4
RCSB/PDB
Inspect Structure
See all 3D Structures for F2rl3

Isoforms / Transcripts (Protein Coding)


Protein Length Ensembl Gene Ensembl Transcript Ensembl Protein Uniprot Isoform
396O88634-1

Sub-cellular localization


UniProt: F2rl3 is active in the following subcellular-locations: cell membrane.
GO terms: F2rl3 is active in the following subcellular-locations: integral component of plasma membrane.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project F2rl3 has gain in 0 cell-lines, loss in 0 cell-lines and no signal in 0 cell-lines. (see details)

3D Structures


For F2rl3 there are:
1 structures (1 chains) solved
0 are solved in complex with at least one small molecule ligand



(see details)
Molecular Target 3D Synopsis

Screening and Chemistry


F2rl3 has been screened with compounds ( bioactivities). (see details)