Molecular Target Synopsis
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dsrF (O87897) - Druggability - Molecular Target Synopsis

Chain-based assessment (last updated 07/05/2019)
Domain-based assessment (last updated 30/07/2012)


Structural Druggability Help: Help

Chain-based assessment (last updated 07/05/2019)


Chains assessed7
Chains with at least one site assessed as druggable using the strict criteria0
Chains with at least one site assessed as druggable using the relaxed criteria2


		
PDB Chain Protein Name Druggable Relaxed Druggable Strict Details
2HYB_B Intracellular sulfur oxidation protein DsrF No No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.46 65.9 23.1 No No
2 empty 2.79 62.8 14 No No
3 empty 1.38 66 10.2 No No
4 empty 2.69 65.7 9.4 No No
5 empty 2.24 70.4 9.9 No No
6 empty 1.88 62.6 13.9 No No
7 empty 1.83 73.8 10.7 No No
8 empty 2.6 61 9.1 No No
9 empty 2.87 68.6 8.6 No No
10 empty 2.15 67.2 8.8 No No
2HYB_Q Intracellular sulfur oxidation protein DsrF Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.59 66.7 32.1 Yes No
2 empty 2.65 66.3 11.3 No No
3 empty 1.43 65.3 11.8 No No
4 empty 2.29 72.2 10.2 No No
5 empty 2.54 65.1 10.7 No No
6 empty 1.78 71.2 10.2 No No
7 empty 3.11 59.9 9.6 No No
8 empty 2.61 73.9 9.8 No No
9 empty 2.81 63.6 11 No No
10 empty 2.13 66.2 5.5 No No
2HYB_H Intracellular sulfur oxidation protein DsrF No No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.51 64.2 20.5 No No
2 empty 2.72 65.5 19.1 No No
3 empty 1.42 67.1 12.9 No No
4 empty 2.55 64.9 10.5 No No
5 empty 2.29 69.8 9.6 No No
6 empty 2.81 61.2 12.2 No No
7 empty 1.93 74 9.5 No No
8 empty 2.76 62.7 8.3 No No
9 empty 2.65 69.2 11.5 No No
10 empty 2.14 71.6 6.3 No No
2HYB_K Intracellular sulfur oxidation protein DsrF No No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.51 65.3 20.9 No No
2 empty 1.5 66.2 13.2 No No
3 empty 2.58 62.5 10.4 No No
4 empty 2.28 73.7 8.5 No No
5 empty 2.58 66.9 11.2 No No
6 empty 2.77 67.9 7.2 No No
7 empty 2.94 69.5 8.3 No No
8 empty 1.75 67.3 10.4 No No
9 empty 2.75 66.5 8.5 No No
10 empty 1.65 64.4 8.9 No No
2HYB_N Intracellular sulfur oxidation protein DsrF No No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.45 64.6 18.5 No No
2 empty 2.74 67.9 11.4 No No
3 empty 1.29 66.4 12.6 No No
4 empty 2.68 62.9 10.4 No No
5 empty 2.3 68 9.5 No No
6 empty 2.87 62.8 15.7 No No
7 empty 2.72 69.1 5.7 No No
8 empty 1.97 74.1 8.5 No No
9 empty 2.93 64 9.3 No No
10 empty 2.04 64.5 9 No No
2HYB_E Intracellular sulfur oxidation protein DsrF No No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.47 64.5 18.9 No No
2 empty 2.29 67.6 13.3 No No
3 empty 2.64 65.3 10.8 No No
4 empty 1.38 66.1 10 No No
5 empty 2.73 67.6 13.8 No No
6 empty 2.45 66 12.1 No No
7 empty 2.14 73.9 9.1 No No
8 empty 3.12 61.4 9.8 No No
9 empty 2.78 61.2 7.9 No No
10 empty 2.02 68.2 5.5 No No
2HY5_B Intracellular sulfur oxidation protein DsrF Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.83 60.8 24.7 Yes No
2 empty 2.79 61 23.2 No No
3 empty 2.36 70 9.2 No No
4 empty 2.78 63.2 10.2 No No
5 empty 1.34 66.8 12.5 No No
6 empty 2.73 66.1 9.1 No No
7 empty 1.89 64.1 10.8 No No
8 empty 1.81 65.3 10.4 No No
9 empty 2.02 65.6 10.6 No No
10 empty 2.42 72.4 7.5 No No

Domain-based assessment (last updated 30/07/2012)


Domains assessed7
Domains assessed as druggable using the strict criteria0
Domains assessed as druggable using the relaxed criteria2

PDB (Domain) Protein Name Domain Resolution Ligands Druggable Relaxed Druggable Strict
2HY5_B (136866) Intracellular sulfur oxidation protein DsrF DsrEFH-like, DsrEFH-like, DsrEF-like 1.7Å Yes No
2HYB_E (147442) Intracellular sulfur oxidation protein DsrF DsrEFH-like, DsrEFH-like, DsrEF-like 2.5Å No No
2HYB_Q (147454) Intracellular sulfur oxidation protein DsrF DsrEFH-like, DsrEFH-like, DsrEF-like 2.5Å Yes No
2HYB_K (147448) Intracellular sulfur oxidation protein DsrF DsrEFH-like, DsrEFH-like, DsrEF-like 2.5Å No No
2HYB_N (147451) Intracellular sulfur oxidation protein DsrF DsrEFH-like, DsrEFH-like, DsrEF-like 2.5Å No No
2HYB_B (147439) Intracellular sulfur oxidation protein DsrF DsrEFH-like, DsrEFH-like, DsrEF-like 2.5Å No No
2HYB_H (147445) Intracellular sulfur oxidation protein DsrF DsrEFH-like, DsrEFH-like, DsrEF-like 2.5Å No No
Ligand-based Druggability Score:
Ligand-based Druggability Score Percentile: %
Ligand-based Druggability Help: Help




		
This protein has no network-based druggability score