Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

pikC (O87605) - Overview - Molecular Target Synopsis

Protein


pikC, Cytochrome P450 monooxygenase PikC
Enzyme Classification 1.14.15.33
UniProt O87605

Also Known as PIKC_STRVZ, pikC, picK

Catalyzes the hydroxylation of narbomycin to give rise to pikromycin, and of 10-deoxymethymycin (YC-17) to give rise to methymycin and neomethymycin during macrolide antibiotic biosynthesis. In addition, produces low amounts of neopicromycin, novapikromycin and novamethymycin. Requires the participation of a ferredoxin and a ferredoxin reductase for the transfer of electrons from NADPH to the monooxygenase.

4UMZ
PIKC D50N MUTANT IN COMPLEX WITH THE ENGINEERED SUBSTRATE MIMIC BEARING A 2-DIMETHYLAMINOMETHYLBENZOATE GROUP
RCSB/PDB
Inspect Structure
See all 3D Structures for pikC

Isoforms / Transcripts (Protein Coding)


Protein Length Ensembl Gene Ensembl Transcript Ensembl Protein Uniprot Isoform
416O87605-1

Gene Copy Number Variation


In COSMIC - Cell Lines Project pikC has gain in 0 cell-lines, loss in 0 cell-lines and no signal in 0 cell-lines. (see details)

RNA Interference


pikC was reported in the following RNAI studies:

Cell - Large Scale Profiling of Kinase Dependencies in Cancer Cell Lines, the highest RNAi cell lines are: . (see details)

3D Structures


For pikC there are:
15 structures (43 chains) solved
15 are solved in complex with at least one small molecule ligand



(see details)
Molecular Target 3D Synopsis