Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

TRIO (O75962) - Overview - Molecular Target Synopsis

Protein


TRIO, Triple functional domain protein
Enzyme Classification 2.7.11.1
UniProt O75962

Also Known as TRIO_HUMAN, TRIO

Guanine nucleotide exchange factor (GEF) for RHOA and RAC1 GTPases (PubMed:8643598, PubMed:22155786, PubMed:27418539). Involved in coordinating actin remodeling, which is necessary for cell migration and growth (PubMed:10341202, PubMed:22155786). In developing hippocampal neurons, limits dendrite formation, without affecting the establishment of axon polarity. Once dendrites are formed, involved in the control of synaptic function by regulating the endocytosis of AMPA-selective glutamate receptors (AMPARs) at CA1 excitatory synapses (By similarity). May act as a regulator of adipogenesis (By similarity). Interacts with CARMIL1 (PubMed:19846667). Interacts with PTPRF/LAR (PubMed:8643598). Interacts with ANKRD26 (PubMed:22666460). Interacts with Bassoon/BSN and Piccolo/PCLO (By similarity). Interacts with the cytoplasmic region of the heterodimer formed by NGFR and SORCS2. ProNGF binding mediates dissociation of TRIO from the receptor complex (PubMed:22155786).

6D8Z
CRYSTAL STRUCTURE OF THE C-TERMINAL GUANINE EXCHANGE FACTOR MODULE OF HUMAN TRIO
RCSB/PDB
Inspect Structure
See all 3D Structures for TRIO

Isoforms / Transcripts (Protein Coding)


Sub-cellular localization


UniProt: TRIO is active in the following subcellular-locations: cell projection, cytoplasm.
GO terms: TRIO is active in the following subcellular-locations: cytosol.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project TRIO has gain in 38 cell-lines, loss in 1 cell-lines and no signal in 966 cell-lines. (see details)

Gene Expression


In NCI60, the highest expressing cell lines are: SN12C, NCI_ADR_RES, HS578T

In Array Express (RNA-seq of 675 commonly used human cancer cell lines), the highest expressing cell lines are: LCLC-103H, HCC4006, JL-1

In Array Express (RNA-seq of long poly adenylated RNA and long non poly adenylated RNA from ENCODE cell lines), the highest expressing cell lines are: SK-N-SH, HSMM, NHLF

(see details)

RNA Interference


TRIO was reported in the following RNAI studies:

Cell - Large Scale Profiling of Kinase Dependencies in Cancer Cell Lines, the highest RNAi cell lines are: SAOS2, MIAPACA2. (see details)

3D Structures


For TRIO there are:
3 structures (5 chains) solved
0 are solved in complex with at least one small molecule ligand



(see details)
Molecular Target 3D Synopsis

Screening and Chemistry


TRIO has been screened with compounds ( bioactivities). (see details)