Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

BBOX1 (O75936) - Overview - Molecular Target Synopsis

Protein


BBOX1, Gamma-butyrobetaine dioxygenase
Enzyme Classification 1.14.11.1
UniProt O75936

Also Known as BODG_HUMAN, BBOX1, BBH, BBOX

Catalyzes the formation of L-carnitine from gamma-butyrobetaine.

4CWD
CRYSTAL STRUCTURE OF HUMAN GAMMA-BUTYROBETAINE,2-OXOGLUTARATE IN COMPLEX WITH 449, A NOVEL SUBSTRATE
RCSB/PDB
Inspect Structure
See all 3D Structures for BBOX1

Isoforms / Transcripts (Protein Coding)


Sub-cellular localization


UniProt: BBOX1 is active in the following subcellular-locations: cytoplasm.
GO terms: BBOX1 is active in the following subcellular-locations: cytosol, extracellular exosome, mitochondrion.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project BBOX1 has gain in 2 cell-lines, loss in 2 cell-lines and no signal in 1001 cell-lines. (see details)

Gene Expression


In NCI60, the highest expressing cell lines are: NCI_H322M, MCF7, OVCAR_3

In Array Express (RNA-seq of 675 commonly used human cancer cell lines), the highest expressing cell lines are: HCC1187, OVSAHO, OCI-LY-10

In Array Express (RNA-seq of long poly adenylated RNA and long non poly adenylated RNA from ENCODE cell lines), the highest expressing cell lines are: SK-N-SH, NHLF, HSMM

(see details)

3D Structures


For BBOX1 there are:
12 structures (17 chains) solved
11 are solved in complex with at least one small molecule ligand



(see details)
Molecular Target 3D Synopsis

Screening and Chemistry


BBOX1 has been screened with 74 compounds (161 bioactivities), 4 compounds have bioactivities that show binding affinity of <= 500nM (4 bioactivities). (see details)