Molecular Target Synopsis
Overview
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Drugs and Clinical Candidates
Druggability
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SCO1 (O75880) - Druggability - Molecular Target Synopsis

Chain-based assessment (last updated 02/07/2019)
Domain-based assessment (last updated 30/07/2012)


Structural Druggability Help: Help

Chain-based assessment (last updated 02/07/2019)


Chains assessed13
Chains with at least one site assessed as druggable using the strict criteria1
Chains with at least one site assessed as druggable using the relaxed criteria8


		
PDB Chain Protein Name Druggable Relaxed Druggable Strict Details
2GQL_A Protein SCO1 homolog, mitochondrial Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.15 63.9 34.6 Yes No
2 empty 1.71 56.3 20.1 No No
3 empty 1.99 64.5 21.8 No No
4 empty 2.25 58.3 15.7 No No
5 empty 1.98 65.3 17.4 No No
6 empty 1.94 63.4 19.3 No No
7 empty 2.02 62.7 10.5 No No
8 empty 2.7 61.6 12.2 No No
9 empty 2.27 72.7 9.5 No No
10 empty 2.05 62.4 10.8 No No
2GT6_A Protein SCO1 homolog, mitochondrial Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.4 65.3 31.7 Yes No
2 empty 1.65 62.3 12.6 No No
3 empty 1.98 53.4 11.1 No No
4 empty 2.2 62.3 13.1 No No
5 empty 1.76 67.7 8.7 No No
6 empty 1.82 66.7 13.5 No No
7 empty 1.93 61.3 9.8 No No
8 empty 1.97 66.5 10.4 No No
9 empty 2.34 55.6 8.8 No No
10 empty 2.28 55.3 13.9 No No
2GQK_A Protein SCO1 homolog, mitochondrial Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 1.74 56.5 24 Yes No
2 empty 2.29 66.4 16.6 No No
3 empty 2.44 53.6 16.8 No No
4 empty 2.18 61.9 16.2 No No
5 empty 2.25 59.1 11.1 No No
6 empty 1.77 63.8 15.9 No No
7 empty 1.96 64.5 14.2 No No
8 empty 2.61 62.5 18.4 No No
9 empty 1.82 62.7 15.1 No No
10 empty 2.12 62.3 11 No No
1WP0_C Protein SCO1 homolog, mitochondrial Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.4 67 28.5 Yes No
2 empty 2.26 61 25.9 No No
3 empty 2.21 65.2 17.8 No No
4 empty 2.49 61.6 11.4 No No
5 empty 1.68 79.5 10.5 No No
6 empty 1.93 68.7 11.4 No No
7 empty 1.59 68.2 9.9 No No
8 empty 2.33 57.8 16.9 No No
9 empty 2.14 60.7 10.8 No No
10 empty 1.98 67 10.3 No No
1WP0_B Protein SCO1 homolog, mitochondrial No No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.31 66.7 21.1 No No
2 empty 2.26 66.8 16.4 No No
3 empty 2.1 60.6 17.8 No No
4 empty 2.31 70.2 8.7 No No
5 empty 2.03 71.1 10.7 No No
6 empty 1.72 81.9 12.1 No No
7 empty 2.42 60.5 12.5 No No
8 empty 1.96 67.9 17.2 No No
9 empty 2.19 55.8 16.6 No No
10 empty 1.75 64.5 12.9 No No
2HRF_A Protein SCO1 homolog, mitochondrial No No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.02 62.5 23.1 No No
2 empty 2.03 65.7 29.9 No No
3 empty 2.24 58.3 27.2 No No
4 empty 2.27 67.7 19.1 No No
5 empty 1.79 71.1 10.9 No No
6 empty 1.93 62.6 16.6 No No
7 empty 1.97 66.2 12.5 No No
8 empty 2.76 62.8 9.3 No No
9 empty 2.34 74.8 10.5 No No
10 empty 2.35 62.2 11.7 No No
2GGT_B Protein SCO1 homolog, mitochondrial No No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.29 66.9 20 No No
2 empty 2.15 63.6 25.9 No No
3 empty 1.74 71.5 12 No No
4 empty 2.36 59.8 21.6 No No
5 empty 2.31 71.8 12.4 No No
6 empty 2.57 64.6 14.4 No No
7 empty 1.98 71.4 8.5 No No
8 empty 2.17 63.1 13.2 No No
9 empty 2.16 76.8 8.2 No No
10 empty 2.3 54.4 14.8 No No
2HRN_A Protein SCO1 homolog, mitochondrial Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.17 59.9 29 Yes No
2 empty 2.5 74.6 16.3 No No
3 empty 2.11 66.7 14.8 No No
4 empty 2.07 60.8 23.1 No No
5 empty 1.37 67.1 12.2 No No
6 empty 2.53 63.9 13.6 No No
7 empty 1.88 68.2 11.7 No No
8 empty 2.4 63.7 9.6 No No
9 empty 2.09 61 14.3 No No
10 empty 2.69 54.9 9 No No
2GQM_A Protein SCO1 homolog, mitochondrial Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 1.91 63.7 42.5 Yes No
2 empty 2.13 65.2 16.7 No No
3 empty 2.03 57.8 13.1 No No
4 empty 1.91 63.7 12.2 No No
5 empty 1.89 64.5 10.7 No No
6 empty 2.38 61 10.8 No No
7 empty 2.36 53.8 8.8 No No
8 empty 2.25 67.8 7.1 No No
9 empty 3.08 63.2 8.7 No No
10 empty 2.1 70.9 5.4 No No
1WP0_A Protein SCO1 homolog, mitochondrial No No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.28 69.9 19.5 No No
2 empty 1.88 58.5 19 No No
3 empty 2.01 64.4 18 No No
4 empty 2.32 61.8 10.6 No No
5 empty 2.36 65.2 11.2 No No
6 empty 1.79 72.6 9.9 No No
7 empty 2 76.4 13.7 No No
8 empty 1.88 67.4 12.3 No No
9 empty 2.28 61.8 11.3 No No
10 empty 2.05 59.5 9.7 No No
2GGT_A Protein SCO1 homolog, mitochondrial No No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.61 67.8 22.5 No No
2 empty 2.25 65 24.4 No No
3 empty 2.25 69.5 15.6 No No
4 empty 2.6 63.9 13.6 No No
5 empty 2.45 67.7 9.2 No No
6 empty 1.99 75.4 10.7 No No
7 empty 2.46 61.8 14 No No
8 empty 2.31 56.6 11.1 No No
9 empty 2.13 60.4 8.1 No No
10 empty 2.31 65.6 13.5 No No
2GT5_A Protein SCO1 homolog, mitochondrial Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.07 63.9 32 Yes No
2 empty 1.63 69.4 35.1 No No
3 empty 1.96 66 29.8 No No
4 empty 2.02 77.2 10.4 No No
5 empty 1.88 70.4 12.6 No No
6 empty 1.76 85.8 15.2 Yes No
7 empty 2.31 68.6 10.7 No No
8 empty 1.35 100 0 Yes No
9 empty 1.77 68.9 10.1 No No
10 empty 2.17 60.3 10.7 No No
2GVP_A Protein SCO1 homolog, mitochondrial Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 1.97 72.9 36 Yes Yes
2 empty 1.85 58.3 19.4 No No
3 empty 2.04 65.8 16.1 No No
4 empty 1.79 58.1 17.1 No No
5 empty 2.35 55.3 15.3 No No
6 empty 1.95 70.9 11.4 No No
7 empty 1.84 59.7 10.5 No No
8 empty 2.19 61.8 18.1 No No
9 empty 2 63.8 8.8 No No
10 empty 2.17 69.9 9.5 No No

Domain-based assessment (last updated 30/07/2012)


Domains assessed13
Domains assessed as druggable using the strict criteria1
Domains assessed as druggable using the relaxed criteria11

PDB (Domain) Protein Name Domain Resolution Ligands Druggable Relaxed Druggable Strict
1WP0_A (121132) Protein SCO1 homolog, mitochondrial Thioredoxin fold, Thioredoxin-like, Glutathione peroxidase-like 2.8Å Yes No
1WP0_B (121133) Protein SCO1 homolog, mitochondrial Thioredoxin fold, Thioredoxin-like, Glutathione peroxidase-like 2.8Å Yes No
1WP0_C (121134) Protein SCO1 homolog, mitochondrial Thioredoxin fold, Thioredoxin-like, Glutathione peroxidase-like 2.8Å Yes No
2GGT_A (135156) Protein SCO1 homolog, mitochondrial Thioredoxin fold, Thioredoxin-like, Glutathione peroxidase-like 2.4Å No No
2GGT_B (135157) Protein SCO1 homolog, mitochondrial Thioredoxin fold, Thioredoxin-like, Glutathione peroxidase-like 2.4Å Yes No
2GQK_A (3100324) Protein SCO1 homolog, mitochondrial Thioredoxin fold, Thioredoxin-like, UNMATCHED Yes No
2GQL_A (3100325) Protein SCO1 homolog, mitochondrial Thioredoxin fold, Thioredoxin-like, UNMATCHED Yes No
2GQM_A (3100326) Protein SCO1 homolog, mitochondrial Thioredoxin fold, Thioredoxin-like, UNMATCHED Yes No
2GT5_A (3100435) Protein SCO1 homolog, mitochondrial Thioredoxin fold, Thioredoxin-like, UNMATCHED Yes No
2GT6_A (3100436) Protein SCO1 homolog, mitochondrial Thioredoxin fold, Thioredoxin-like, UNMATCHED Yes No
2GVP_A (3100491) Protein SCO1 homolog, mitochondrial Thioredoxin fold, Thioredoxin-like, UNMATCHED Yes Yes
2HRF_A (3110458) Protein SCO1 homolog, mitochondrial Thioredoxin fold, Thioredoxin-like, UNMATCHED No No
2HRN_A (3110465) Protein SCO1 homolog, mitochondrial Thioredoxin fold, Thioredoxin-like, UNMATCHED Yes No
Ligand-based Druggability Score: -3
Ligand-based Druggability Score Percentile: 59%
Ligand-based Druggability Help: Help




		
Number of proteins in the network : 13346


SCO1 is involved in 1 interactions in the network.


Druggability
Overall Druggability Percentile: 40.37
Druggability for Cancer Therapeutics: 3.68
Druggability for Other Therapeutics: 81.60
Cancer-Associated
Cancer-associated percentile : 2.96
Network Articulation Point
Is SCO1 critical for communication in the network?


Detailed Graph Legend:Help