Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

SCO1 (O75880) - Overview - Molecular Target Synopsis

Protein


SCO1, Protein SCO1 homolog, mitochondrial
UniProt O75880

Also Known as SCO1_HUMAN, SCO1, SCOD1

Copper metallochaperone essential for the maturation of cytochrome c oxidase subunit II (MT-CO2/COX2). Not required for the synthesis of MT-CO2/COX2 but plays a crucial role in stabilizing MT-CO2/COX2 during its subsequent maturation. Involved in transporting copper to the Cu(A) site on MT-CO2/COX2 (PubMed:15659396, PubMed:16735468, PubMed:17189203, PubMed:19336478, PubMed:15229189). Plays an important role in the regulation of copper homeostasis by controlling the abundance and cell membrane localization of copper transporter CTR1 (By similarity). Homodimer (PubMed:16735468, PubMed:15229189). Interacts with COA6 (PubMed:26160915). Found in a complex with TMEM177, COX20, COA6, MT-CO2/COX2, COX18 and SCO2 (PubMed:29154948). Interacts with TMEM177 in a COX20-dependent manner (PubMed:29154948). Interacts with COX20 in a MT-CO2/COX2- and COX18-dependent manner (PubMed:29154948, PubMed:24403053, PubMed:28330871). Interacts with COX16 (PubMed:29381136).

2HRF
SOLUTION STRUCTURE OF CU(I) P174L HSCO1
RCSB/PDB
Inspect Structure
See all 3D Structures for SCO1

Isoforms / Transcripts (Protein Coding)


Sub-cellular localization


UniProt: SCO1 is active in the following subcellular-locations: mitochondrion, mitochondrion inner membrane.
GO terms: SCO1 is active in the following subcellular-locations: host cell mitochondrial intermembrane space, integral component of mitochondrial inner membrane, mitochondrial inner membrane, mitochondrion, myofibril.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project SCO1 has gain in 0 cell-lines, loss in 10 cell-lines and no signal in 995 cell-lines. (see details)

Gene Expression


In NCI60, the highest expressing cell lines are: HCC_2998, OVCAR_3, A549

In Array Express (RNA-seq of 675 commonly used human cancer cell lines), the highest expressing cell lines are: KYSE-150, KYSE-30, 143B

In Array Express (RNA-seq of long poly adenylated RNA and long non poly adenylated RNA from ENCODE cell lines), the highest expressing cell lines are: SK-N-SH, A549, BJ

(see details)

3D Structures


For SCO1 there are:
10 structures (13 chains) solved
0 are solved in complex with at least one small molecule ligand



(see details)
Molecular Target 3D Synopsis