Molecular Target Synopsis
Domains and Structures
Drugs and Clinical Candidates
Ligand Efficiency Plot
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
Germline Genetics

SCO1 (O75880) - Overview - Molecular Target Synopsis


SCO1, Protein SCO1 homolog, mitochondrial
UniProt O75880

Also Known as SCO1_HUMAN, SCO1, SCOD1

Copper metallochaperone essential for the maturation of cytochrome c oxidase subunit II (MT-CO2/COX2). Not required for the synthesis of MT-CO2/COX2 but plays a crucial role in stabilizing MT-CO2/COX2 during its subsequent maturation. Involved in transporting copper to the Cu(A) site on MT-CO2/COX2 (PubMed:15659396, PubMed:16735468, PubMed:17189203, PubMed:19336478, PubMed:15229189). Plays an important role in the regulation of copper homeostasis by controlling the abundance and cell membrane localization of copper transporter CTR1 (By similarity). Homodimer (PubMed:16735468, PubMed:15229189). Interacts with COA6 (PubMed:26160915). Found in a complex with TMEM177, COX20, COA6, MT-CO2/COX2, COX18 and SCO2 (PubMed:29154948). Interacts with TMEM177 in a COX20-dependent manner (PubMed:29154948). Interacts with COX20 in a MT-CO2/COX2- and COX18-dependent manner (PubMed:29154948, PubMed:24403053, PubMed:28330871). Interacts with COX16 (PubMed:29381136).

Inspect Structure
See all 3D Structures for SCO1

Isoforms / Transcripts (Protein Coding)

Sub-cellular localization

UniProt: SCO1 is active in the following subcellular-locations: mitochondrion, mitochondrion inner membrane.
GO terms: SCO1 is active in the following subcellular-locations: host cell mitochondrial intermembrane space, integral component of mitochondrial inner membrane, mitochondrial inner membrane, mitochondrion, myofibril.

GO terms

Gene Copy Number Variation

In COSMIC - Cell Lines Project SCO1 has gain in 0 cell-lines, loss in 10 cell-lines and no signal in 995 cell-lines. (see details)

Gene Expression

In NCI60, the highest expressing cell lines are: HCC_2998, OVCAR_3, A549

In Array Express (RNA-seq of 675 commonly used human cancer cell lines), the highest expressing cell lines are: KYSE-150, KYSE-30, 143B

In Array Express (RNA-seq of long poly adenylated RNA and long non poly adenylated RNA from ENCODE cell lines), the highest expressing cell lines are: SK-N-SH, A549, BJ

(see details)

3D Structures

For SCO1 there are:
10 structures (13 chains) solved
0 are solved in complex with at least one small molecule ligand

(see details)
Molecular Target 3D Synopsis