Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

CRTAP (O75718) - Overview - Molecular Target Synopsis

Protein


CRTAP, Cartilage-associated protein
UniProt O75718

Also Known as CRTAP_HUMAN, CRTAP, CASP

Necessary for efficient 3-hydroxylation of fibrillar collagen prolyl residues.

Isoforms / Transcripts (Protein Coding)


Protein Length Ensembl Gene Ensembl Transcript Ensembl Protein Uniprot Isoform
401ENSG00000170275ENST00000320954ENSP00000323696O75718-1
358ENSG00000170275ENST00000449224ENSP00000409997

Sub-cellular localization


UniProt: CRTAP is active in the following subcellular-locations: extracellular matrix, extracellular space, secreted.
GO terms: CRTAP is active in the following subcellular-locations: endoplasmic reticulum, endoplasmic reticulum lumen, extracellular space, protein-containing complex.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project CRTAP has gain in 1 cell-lines, loss in 3 cell-lines and no signal in 1001 cell-lines. (see details)

Gene Expression


In NCI60, the highest expressing cell lines are: M14, MALME_3M, SK_MEL_2

In Array Express (RNA-seq of 675 commonly used human cancer cell lines), the highest expressing cell lines are: HT-144, NCI-H2452, Hs 746T

In Array Express (RNA-seq of long poly adenylated RNA and long non poly adenylated RNA from ENCODE cell lines), the highest expressing cell lines are: NHLF, HSMM, BJ

(see details)