Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

STK16 (O75716) - Overview - Molecular Target Synopsis

Protein


STK16, Serine/threonine-protein kinase 16
Enzyme Classification 2.7.11.1
UniProt O75716

Also Known as STK16_HUMAN, STK16, MPSK1, PKL12, TSF1

Membrane-associated protein kinase that phosphorylates on serine and threonine residues. In vitro substrates include DRG1, ENO1 and EIF4EBP1. Also autophosphorylates. May be involved in secretory vesicle trafficking or intracellular signaling. May have a role in regulating stromal-epithelial interactions that occur during ductal morphogenesis in the mammary gland. May be involved in TGF-beta signaling. Able to autophosphorylate on Tyr residue; it is however unclear whether it has tyrosine-protein kinase toward other proteins. Monomer. Interacts with DRG1 (via its N-terminal); the interaction phosphorylates DRG1.

2BUJ
CRYSTAL STRUCTURE OF THE HUMAN SERINE-THREONINE KINASE 16 IN COMPLEX WITH STAUROSPORINE
RCSB/PDB
Inspect Structure
See all 3D Structures for STK16

Isoforms / Transcripts (Protein Coding)


Sub-cellular localization


UniProt: STK16 is active in the following subcellular-locations: cytoplasm, membrane, perinuclear region.
GO terms: STK16 is active in the following subcellular-locations: cytosol, Golgi-associated vesicle, membrane, perinuclear region of cytoplasm.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project STK16 has gain in 0 cell-lines, loss in 1 cell-lines and no signal in 1004 cell-lines. (see details)

Gene Expression


In NCI60, the highest expressing cell lines are: COLO205, HOP_62, T47D

In Array Express (RNA-seq of 675 commonly used human cancer cell lines), the highest expressing cell lines are: DMS 53, NCI-H1373, DMS 454

In Array Express (RNA-seq of long poly adenylated RNA and long non poly adenylated RNA from ENCODE cell lines), the highest expressing cell lines are: SK-N-SH, K562, A549

(see details)

RNA Interference


STK16 was reported in the following RNAI studies:

Cell - Large Scale Profiling of Kinase Dependencies in Cancer Cell Lines, the highest RNAi cell lines are: MCF12A, OVISE. (see details)

3D Structures


For STK16 there are:
1 structures (2 chains) solved
1 are solved in complex with at least one small molecule ligand



(see details)
Molecular Target 3D Synopsis

Screening and Chemistry


STK16 has been screened with 331 compounds (414 bioactivities), 17 compounds have bioactivities that show binding affinity of <= 500nM (27 bioactivities). (see details)