Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

PPM1B (O75688) - Overview - Molecular Target Synopsis

Protein


PPM1B, Protein phosphatase 1B
Enzyme Classification 3.1.3.16
UniProt O75688

Also Known as PPM1B_HUMAN, PPM1B, PP2CB

Enzyme with a broad specificity. Dephosphorylates CDK2 and CDK6 in vitro. Dephosphorylates PRKAA1 and PRKAA2. Inhibits TBK1-mediated antiviral signaling by dephosphorylating it at 'Ser-172'. Plays an important role in the termination of TNF-alpha-mediated NF-kappa-B activation through dephosphorylating and inactivating IKBKB/IKKB. Monomer (By similarity). Interacts with PAK6. Interacts with the phosphorylated form of IKBKB/IKKB.

2P8E
CRYSTAL STRUCTURE OF THE SERINE/THREONINE PHOSPHATASE DOMAIN OF HUMAN PPM1B
RCSB/PDB
Inspect Structure
See all 3D Structures for PPM1B

Isoforms / Transcripts (Protein Coding)


Sub-cellular localization


UniProt: PPM1B is active in the following subcellular-locations: cytoplasm, cytosol, membrane.
GO terms: PPM1B is active in the following subcellular-locations: cytosol, membrane, nucleolus, nucleus.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project PPM1B has gain in 2 cell-lines, loss in 0 cell-lines and no signal in 1002 cell-lines. (see details)

Gene Expression


In NCI60, the highest expressing cell lines are: IGROV1, OVCAR_5, ACHN

In Array Express (RNA-seq of 675 commonly used human cancer cell lines), the highest expressing cell lines are: PA-1, DMS 53, OVMANA

In Array Express (RNA-seq of long poly adenylated RNA and long non poly adenylated RNA from ENCODE cell lines), the highest expressing cell lines are: MCF-7, NHLF, A549

(see details)

3D Structures


For PPM1B there are:
1 structures (2 chains) solved
1 are solved in complex with at least one small molecule ligand



(see details)
Molecular Target 3D Synopsis

Screening and Chemistry


PPM1B has been screened with 60 compounds (65 bioactivities), 3 compounds have bioactivities that show binding affinity of <= 500nM (4 bioactivities). (see details)