Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

FCN3 (O75636) - Overview - Molecular Target Synopsis

Protein


FCN3, Ficolin-3
UniProt O75636

Also Known as FCN3_HUMAN, FCN3, FCNH, HAKA1

May function in innate immunity through activation of the lectin complement pathway. Calcium-dependent and GlcNAc-binding lectin. Has affinity with GalNAc, GlcNAc, D-fucose, as mono/oligosaccharide and lipopolysaccharides from S.typhimurium and S.minnesota. Homotrimer (PubMed:17215869). May form an octadecamer consisting of an elementary trimer unit. Does not interact with fibronectin, elastin or zymosan. Interacts with MASP1 and MASP2.

2J5Z
H-FICOLIN COMPLEXED TO GALACTOSE
RCSB/PDB
Inspect Structure
See all 3D Structures for FCN3

Isoforms / Transcripts (Protein Coding)


Protein Length Ensembl Gene Ensembl Transcript Ensembl Protein Uniprot Isoform
299ENSG00000142748ENST00000270879ENSP00000270879O75636-1
288ENSG00000142748ENST00000354982ENSP00000347077O75636-2

Sub-cellular localization


UniProt: FCN3 is active in the following subcellular-locations: secreted.
GO terms: FCN3 is active in the following subcellular-locations: blood microparticle, collagen trimer, extracellular region.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project FCN3 has gain in 1 cell-lines, loss in 1 cell-lines and no signal in 1002 cell-lines. (see details)

Gene Expression


In NCI60, the highest expressing cell lines are: UACC_62, BT_549, LOXIMVI

In Array Express (RNA-seq of 675 commonly used human cancer cell lines), the highest expressing cell lines are: Hs 746T, NCI-H209, SK-N-FI

In Array Express (RNA-seq of long poly adenylated RNA and long non poly adenylated RNA from ENCODE cell lines), the highest expressing cell lines are: SK-N-SH, NHLF, HSMM

(see details)

RNA Interference


FCN3 was reported in the following RNAI studies:

Cell - Large Scale Profiling of Kinase Dependencies in Cancer Cell Lines, the highest RNAi cell lines are: . (see details)

3D Structures


For FCN3 there are:
3 structures (9 chains) solved
2 are solved in complex with at least one small molecule ligand



(see details)
Molecular Target 3D Synopsis

Screening and Chemistry


FCN3 has been screened with compounds ( bioactivities). (see details)