Molecular Target Synopsis
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Domains and Structures
Drugs and Clinical Candidates
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Ligand Efficiency Plot
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LRP6 (O75581) - Domains And Structures - Molecular Target Synopsis

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Structural Sequence Similarity Matches
Domains Covered Gene Name (Uniprot) Solved in Complex with Organism PDB Chain Identity E-Value Resolution Ligands Release Date
Low-density lipoprotein receptor repeat class B (100%), Coagulation Factor Xa inhibitory site (92%) (view alignment) Lrp4 (Q9QYP1) Agrn (P25304) RAT 3V65_D 51.61 6.0E-82 3.3Å - 2012-04-25
Low-density lipoprotein receptor repeat class B (100%), Coagulation Factor Xa inhibitory site (100%) (view alignment) LRP6 (O75581) - HUMAN 6H16_A 100 1.0E-130 2.9Å NAG BMA MAN 2019-01-30
(view alignment) LRP6 (O75581), Gsk3b (Q9WV60) - HUMAN, MOUSE 5AIR_A 100 0 2.53Å - 2015-04-01
Low-density lipoprotein receptor repeat class B (100%), Coagulation Factor Xa inhibitory site (100%) (view alignment) LDLR (P01130) - HUMAN 1IJQ_A 36.1 5.0E-30 1.5Å - 2001-05-23
Low-density lipoprotein receptor repeat class B (100%), Coagulation Factor Xa inhibitory site (100%) (view alignment) LDLR (P01130) PCSK9 (Q8NBP7) HUMAN 3P5C_L 35.4 2.0E-56 4.2Å - 2011-10-26
Low-density lipoprotein receptor repeat class B (100%), Coagulation Factor Xa inhibitory site (100%) (view alignment) LRP6 (O75581) - HUMAN 3S94_A 100 0 2.8Å NAG 2011-11-02
Low-density lipoprotein receptor repeat class B (100%), Coagulation Factor Xa inhibitory site (100%) (view alignment) LRP6 (O75581) DKK1 (O94907) HUMAN 3S8V_A 100 0 3.05Å - 2011-10-26
Low-density lipoprotein receptor repeat class B (100%), Coagulation Factor Xa inhibitory site (100%) (view alignment) LDLR (P01130) - HUMAN 1IJQ_B 36.1 5.0E-30 1.5Å - 2001-05-23
Low-density lipoprotein receptor repeat class B (100%), Coagulation Factor Xa inhibitory site (100%) (view alignment) LRP6 (O75581) - HUMAN 3S8Z_A 100 0 2.75Å NAG 2011-10-26
Low-density lipoprotein receptor repeat class B (100%), Coagulation Factor Xa inhibitory site (100%) (view alignment) LRP6 (O75581) - HUMAN 3S94_B 100 0 2.8Å - 2011-11-02
Low-density lipoprotein receptor repeat class B (100%), Coagulation Factor Xa inhibitory site (100%) (view alignment) LRP6 (O75581) DKK1 (O94907) HUMAN 5GJE_B 100 0 21Å NAG FUC 2017-01-18
Low-density lipoprotein receptor repeat class B (100%), Coagulation Factor Xa inhibitory site (100%) (view alignment) Lrp4 (Q9QYP1) Agrn (P25304) RAT 3V64_C 51.61 5.0E-82 2.85Å NAG 2012-04-25
Low-density lipoprotein receptor repeat class B (100%), Coagulation Factor Xa inhibitory site (100%) (view alignment) LRP6 (O75581) DKK1 (O94907), KREMEN1 (Q96MU8) HUMAN 5FWW_A 100 0 3.5Å - 2016-07-20
Low-density lipoprotein receptor repeat class B (100%), Coagulation Factor Xa inhibitory site (100%), Low-density lipoprotein receptor domain class A (100%) (view alignment) LRP8 (Q14114) Reln (Q60841) HUMAN 5B4X_D 37.34 4.0E-14 3.2Å NAG 2017-04-26
Low-density lipoprotein receptor repeat class B (100%), Coagulation Factor Xa inhibitory site (100%), Low-density lipoprotein receptor domain class A (98%) (view alignment) LDLR (P01130) - HUMAN 1N7D_A 42.86 4.0E-19 3.7Å NAG KEG BMA MAN 2003-01-21
Low-density lipoprotein receptor repeat class B (100%), Coagulation Factor Xa inhibitory site (100%), Low-density lipoprotein receptor domain class A (98%) (view alignment) LDLR (P01130) PCSK9 (Q8NBP7) HUMAN 3M0C_C 42.86 1.0E-19 7.01Å - 2011-03-16
Low-density lipoprotein receptor repeat class B (100%), Coagulation Factor Xa inhibitory site (92%) (view alignment) Lrp4 (Q9QYP1) Agrn (P25304) RAT 3V65_B 51.61 6.0E-82 3.3Å - 2012-04-25
Low-density lipoprotein receptor repeat class B (100%), Coagulation Factor Xa inhibitory site (100%) (view alignment) LRP6 (O75581) DKK1 (O94907) HUMAN 3SOQ_A 100 2.0E-42 1.9Å NAG FUC 2011-09-21
Low-density lipoprotein receptor repeat class B (100%), Coagulation Factor Xa inhibitory site (100%) (view alignment) LRP6 (O75581) - HUMAN 6H15_A 100 0 2.6Å NAG BMA 2019-01-30
Low-density lipoprotein receptor repeat class B (100%), Coagulation Factor Xa inhibitory site (100%) (view alignment) LRP6 (O75581) DKK1 (O94907) HUMAN 5GJE_A 100 0 21Å NAG 2017-01-18
Low-density lipoprotein receptor repeat class B (100%), Coagulation Factor Xa inhibitory site (100%) (view alignment) LRP6 (O75581) DKK1 (O94907) HUMAN 3S2K_B 100 0 2.75Å NAG FUC 2011-11-02
Low-density lipoprotein receptor repeat class B (100%), Coagulation Factor Xa inhibitory site (100%) (view alignment) LRP6 (O75581) - HUMAN 3SOB_B 100 1.0E-71 1.9Å - 2011-09-21
Low-density lipoprotein receptor repeat class B (100%), Coagulation Factor Xa inhibitory site (100%) (view alignment) LRP6 (O75581) DKK1 (O94907) HUMAN 3S8V_B 100 0 3.05Å - 2011-10-26
Low-density lipoprotein receptor domain class A (100%) (view alignment) VLDLR (P98155) - HUMAN 6BYV_A 40.98 2.0E-15 - 2018-07-18
(view alignment) LRP6 (O75581), Gsk3b (Q9WV60) - HUMAN, MOUSE 5AIR_B 100 0 2.53Å - 2015-04-01
Low-density lipoprotein receptor repeat class B (100%), Coagulation Factor Xa inhibitory site (100%) (view alignment) LRP6 (O75581) - HUMAN 6H15_B 100 0 2.6Å NAG BMA MAN 2019-01-30
Low-density lipoprotein receptor repeat class B (100%), Coagulation Factor Xa inhibitory site (100%) (view alignment) LRP6 (O75581) SOST (Q9BQB4) HUMAN 3SOV_A 100 2.0E-42 1.27Å NAG FUC 2011-09-21
Low-density lipoprotein receptor repeat class B (100%), Coagulation Factor Xa inhibitory site (100%), Low-density lipoprotein receptor domain class A (100%) (view alignment) LRP8 (Q14114) Reln (Q60841) HUMAN 5B4X_B 37.34 4.0E-14 3.2Å NAG 2017-04-26
Low-density lipoprotein receptor repeat class B (100%), Coagulation Factor Xa inhibitory site (100%) (view alignment) LRP6 (O75581) DKK1 (O94907) HUMAN 3S2K_A 100 0 2.75Å NAG FUC 2011-11-02
Low-density lipoprotein receptor repeat class B (100%), Coagulation Factor Xa inhibitory site (100%) (view alignment) Lrp4 (Q9QYP1) Agrn (P25304) RAT 3V64_D 51.61 5.0E-82 2.85Å - 2012-04-25
Low-density lipoprotein receptor repeat class B (100%), Coagulation Factor Xa inhibitory site (100%) (view alignment) LRP6 (O75581) - HUMAN 4A0P_A 100 1.0E-130 1.9Å NAG 2011-10-26
Low-density lipoprotein receptor repeat class B (100%), Coagulation Factor Xa inhibitory site (100%), Low-density lipoprotein receptor domain class A (6%) (view alignment) LRP6 (O75581) - HUMAN 4DG6_A 100 2.0E-41 2.88Å NAG 2012-06-13
(view alignment) LRP6 (O75581) AXIN1 (O15169), GSK3B (P49841) 4NM5_C 100 0 2.3Å - 2014-03-26
(view alignment) LRP6 (O75581) AXIN1 (O15169), GSK3B (P49841) 4NM7_C 100 0 2.3Å - 2014-03-26
Low-density lipoprotein receptor repeat class B (100%) (view alignment) Nid1 (P10493) Lamc1 (P02468) HOUSE MOUSE 1NPE_A 39.5 2.0E-20 2.3Å - 2003-08-12
Low-density lipoprotein receptor repeat class B (100%), Coagulation Factor Xa inhibitory site (100%) (view alignment) LDLR (P01130) PCSK9 (Q8NBP7) HUMAN 3P5B_L 35.4 6.0E-56 3.3Å - 2011-10-26