Molecular Target Synopsis
Overview
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Drugs and Clinical Candidates
Druggability
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Ligand Efficiency Plot
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LRP6 (O75581) - Pathways - Molecular Target Synopsis

Data acquired from 29 pathway associations found
Pathway Name Source
Disassembly of the destruction complex and recruitment of AXIN to the membraneReactome v61 (only 'Homo_sapiens.owl') 23-Jun-2017
Negative regulation of TCF-dependent signaling by WNT ligand antagonistsReactome v61 (only 'Homo_sapiens.owl') 23-Jun-2017
Regulation of FZD by ubiquitinationReactome v61 (only 'Homo_sapiens.owl') 23-Jun-2017
RNF mutants show enhanced WNT signaling and proliferationReactome v61 (only 'Homo_sapiens.owl') 23-Jun-2017
TCF dependent signaling in response to WNTReactome v61 (only 'Homo_sapiens.owl') 23-Jun-2017
Alzheimer disease-presenilin pathwayPANTHER Pathways 3.4.1 on 04-Jul-2016 (auto-converted to human-only model)
Canonical Wnt signaling pathway ( C. elegans endoderm induction Wnt signaling pathway Diagram )INOH 4.0 (signal transduction and metabolic data), 22-MAR-2011
Canonical Wnt signaling pathway ( Canonical Wnt signaling pathway Diagram )INOH 4.0 (signal transduction and metabolic data), 22-MAR-2011
Canonical Wnt signaling pathway ( Drosophila Wingless/Wnt signaling pathway Diagram )INOH 4.0 (signal transduction and metabolic data), 22-MAR-2011
Canonical Wnt signaling pathway ( Mammalian Wnt signaling pathway Diagram )INOH 4.0 (signal transduction and metabolic data), 22-MAR-2011
Canonical Wnt signaling pathway ( Xenopus axis formation Wnt signaling pathway Diagram )INOH 4.0 (signal transduction and metabolic data), 22-MAR-2011
Mammalian Wnt signaling pathway ( Mammalian Wnt signaling pathway Diagram )INOH 4.0 (signal transduction and metabolic data), 22-MAR-2011
Signaling with Wnt (Canonical) ( C. elegans endoderm induction Wnt signaling pathway Diagram )INOH 4.0 (signal transduction and metabolic data), 22-MAR-2011
Signaling with Wnt (Canonical) ( Canonical Wnt signaling pathway Diagram )INOH 4.0 (signal transduction and metabolic data), 22-MAR-2011
Signaling with Wnt (Canonical) ( Drosophila Wingless/Wnt signaling pathway Diagram )INOH 4.0 (signal transduction and metabolic data), 22-MAR-2011
Signaling with Wnt (Canonical) ( Mammalian Wnt signaling pathway Diagram )INOH 4.0 (signal transduction and metabolic data), 22-MAR-2011
Signaling with Wnt (Canonical) ( Xenopus axis formation Wnt signaling pathway Diagram )INOH 4.0 (signal transduction and metabolic data), 22-MAR-2011
Signaling with Wnt (Mammal) ( Mammalian Wnt signaling pathway Diagram )INOH 4.0 (signal transduction and metabolic data), 22-MAR-2011
Signaling with Wnt (Xenopus) ( Xenopus axis formation Wnt signaling pathway Diagram )INOH 4.0 (signal transduction and metabolic data), 22-MAR-2011
Stabilization and accumulation of cytoplasmic beta-catenin (Canonical) ( C. elegans endoderm induction Wnt signaling pathway Diagram )INOH 4.0 (signal transduction and metabolic data), 22-MAR-2011
Stabilization and accumulation of cytoplasmic beta-catenin (Canonical) ( Canonical Wnt signaling pathway Diagram )INOH 4.0 (signal transduction and metabolic data), 22-MAR-2011
Stabilization and accumulation of cytoplasmic beta-catenin (Canonical) ( Drosophila Wingless/Wnt signaling pathway Diagram )INOH 4.0 (signal transduction and metabolic data), 22-MAR-2011
Stabilization and accumulation of cytoplasmic beta-catenin (Canonical) ( Mammalian Wnt signaling pathway Diagram )INOH 4.0 (signal transduction and metabolic data), 22-MAR-2011
Stabilization and accumulation of cytoplasmic beta-catenin (Canonical) ( Xenopus axis formation Wnt signaling pathway Diagram )INOH 4.0 (signal transduction and metabolic data), 22-MAR-2011
Stabilization and accumulation of cytoplasmic beta-catenin (Mammal) ( Mammalian Wnt signaling pathway Diagram )INOH 4.0 (signal transduction and metabolic data), 22-MAR-2011
Stabilization and accumulation of cytoplasmic beta-catenin (Xenopus) ( Xenopus axis formation Wnt signaling pathway Diagram )INOH 4.0 (signal transduction and metabolic data), 22-MAR-2011
WntNetPath 12/2011
Wnt signaling pathwayPANTHER Pathways 3.4.1 on 04-Jul-2016 (auto-converted to human-only model)
Xenopus axis formation Wnt signaling pathway ( Xenopus axis formation Wnt signaling pathway Diagram )INOH 4.0 (signal transduction and metabolic data), 22-MAR-2011