Molecular Target Synopsis
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LRP6 (O75581) - Druggability - Molecular Target Synopsis

Chain-based assessment (last updated 23/07/2019)
Domain-based assessment (last updated 30/07/2012)


Structural Druggability Help: Help

Chain-based assessment (last updated 23/07/2019)


Chains assessed20
Chains with at least one site assessed as druggable using the strict criteria15
Chains with at least one site assessed as druggable using the relaxed criteria20


		
PDB Chain Protein Name Druggable Relaxed Druggable Strict Details
6H16_A Low-density lipoprotein receptor-related protein 6 Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.19 67.8 66.7 Yes Yes
2 empty 1.72 76.5 45.6 Yes No
3 empty 1.6 99.8 0 Yes No
4 empty 2.11 62.4 20.2 No No
5 empty 2.11 63.8 24.9 No No
6 empty 2.51 71.2 20.2 No No
7 empty 2.12 69.7 12.1 No No
8 empty 2 62.9 27.9 No No
9 empty 1.89 64.8 16.9 No No
10 empty 2.48 74.8 13.2 No No
5AIR_A Low-density lipoprotein receptor-related protein 6 Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 2.06 65.6 42.6 Yes No
2 empty 1.97 58.4 29.2 No No
3 empty 1.99 66.2 21.2 No No
4 empty 2.12 60.1 23.2 No No
5 empty 2.08 66.3 17.1 No No
6 empty 1.91 61.1 15.3 No No
7 empty 2 63.5 15.9 No No
8 empty 1.59 64 14.2 No No
9 empty 2.29 67.4 12.2 No No
10 empty 1.91 62.2 11.4 No No
3S94_A Low-density lipoprotein receptor-related protein 6 Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 1.76 73.8 44.2 Yes Yes
2 empty 2.17 66.2 28.4 No No
3 empty 2.23 71.3 23.6 No No
4 empty 2.69 62.1 27.1 No No
5 empty 2.16 63.3 19.1 No No
6 bound 2.42 66.4 14.2 No No
7 empty 2.6 59.6 22 No No
8 empty 2.36 66 23.4 No No
9 empty 2.65 69.3 13.4 No No
10 empty 1.78 68.4 13.7 No No
3S8V_A Low-density lipoprotein receptor-related protein 6 Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.15 66.6 43.2 Yes Yes
2 empty 1.85 74.7 48.7 No No
3 empty 2.02 74.5 30.7 No No
4 empty 2.14 63 29.4 No No
5 empty 2.31 68.3 21.4 No No
6 empty 2.23 61.2 24.9 No No
7 empty 1.41 99.8 0 Yes No
8 empty 2.5 70.9 19.6 No No
9 empty 2.66 65.9 20.1 No No
10 empty 1.8 68.4 9.6 No No
3S8Z_A Low-density lipoprotein receptor-related protein 6 Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.29 69.7 44.8 Yes Yes
2 empty 1.74 75.4 47.9 Yes No
3 empty 1.67 98.6 0 Yes No
4 empty 2.35 63.7 29 No No
5 empty 1.96 66.6 16.3 No No
6 empty 2.44 58.7 25.1 No No
7 empty 2.44 63.3 20.7 No No
8 bound 1.85 64.7 22.1 No No
9 empty 1.84 64.2 16.9 No No
10 empty 1.8 69.7 13.6 No No
3S94_B Low-density lipoprotein receptor-related protein 6 Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.36 68.1 45.2 Yes Yes
2 empty 2.01 72.4 33.1 No No
3 empty 1.79 90.9 35 Yes No
4 empty 2.13 69.1 24.9 No No
5 empty 2.28 61.6 33.7 No No
6 empty 2.4 66.3 21.8 No No
7 empty 2 71.3 21.8 No No
8 empty 2.12 61.8 18.5 No No
9 empty 2.51 72.9 11 No No
10 empty 1.94 60.1 17.8 No No
5GJE_B Low-density lipoprotein receptor-related protein 6 Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 1.75 70.6 60.5 Yes Yes
2 empty 2.41 62.2 29.2 No No
3 empty 1.55 97.8 0 Yes No
4 empty 2.1 66.7 29 No No
5 empty 1.81 64.3 17.9 No No
6 empty 2.21 64.9 20.4 No No
7 empty 2.84 66.9 22 No No
8 empty 2.29 74.8 11.4 No No
9 empty 2.01 64.8 17.5 No No
10 empty 2.36 66.3 18.6 No No
5FWW_A Low-density lipoprotein receptor-related protein 6 Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 1.71 72.3 57.5 Yes Yes
2 empty 1.97 66.5 47.6 No No
3 empty 2.05 69.4 26.3 No No
4 empty 2.57 65.6 30.4 No No
5 empty 2.37 59.3 28.2 No No
6 empty 2.11 65.7 28.3 No No
7 empty 1.91 70.8 16.4 No No
8 empty 1.52 99.6 0 Yes No
9 empty 2.3 65.3 27.3 No No
10 empty 2.2 71.2 10.3 No No
3SOQ_A Low-density lipoprotein receptor-related protein 6 Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.35 62.6 25.1 Yes No
2 bound 2.25 67.8 20 No No
3 bound 1.97 65.5 22.5 No No
4 empty 2.79 70.5 22.9 No No
5 empty 2.4 75 15.1 No No
6 empty 1.37 99.3 0 Yes No
7 empty 2.27 74.5 13.2 No No
8 empty 1.88 64.9 12.7 No No
9 empty 2.11 64.9 9.9 No No
10 empty 1.87 64.9 10.2 No No
6H15_A Low-density lipoprotein receptor-related protein 6 Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.18 66.4 48.8 Yes Yes
2 empty 1.82 70.7 52.8 No No
3 empty 1.62 99.8 0 Yes No
4 empty 2.52 62.5 39.4 No No
5 empty 2.56 68.7 22.7 No No
6 empty 1.97 69.9 16.6 No No
7 empty 2.36 61.1 20.8 No No
8 empty 1.57 66.8 15.7 No No
9 empty 2.46 64.9 11.6 No No
10 empty 1.57 68.6 10.3 No No
5GJE_A Low-density lipoprotein receptor-related protein 6 Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 1.98 66.4 41.7 Yes Yes
2 empty 1.62 87 31.1 Yes Yes
3 bound 1.72 78.6 33.2 No No
4 empty 2.12 64.9 27.6 No No
5 empty 2.12 65.6 19 No No
6 empty 2.25 71.4 20.5 No No
7 empty 2.29 64.7 19.8 No No
8 empty 2.52 72 15.8 No No
9 empty 2.2 61.6 21.7 No No
10 empty 2.05 66 17.8 No No
3S2K_B Low-density lipoprotein receptor-related protein 6 Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.24 68.4 47.2 Yes Yes
2 empty 1.76 73.3 51.1 No No
3 empty 2.43 62.1 29.5 No No
4 empty 2.57 63.5 26.5 No No
5 empty 1.56 98.2 0 Yes No
6 empty 2.13 66.1 19.2 No No
7 empty 1.95 70 17.7 No No
8 empty 2.23 65 27.6 No No
9 empty 2.07 63.4 22 No No
10 bound 1.87 64.9 18.7 No No
3SOB_B Low-density lipoprotein receptor-related protein 6 Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.34 64.7 26.7 Yes No
2 empty 2.18 65.8 20.5 No No
3 empty 2.71 65.9 24.3 No No
4 empty 2.18 62.2 25.9 No No
5 empty 1.4 100 0 Yes No
6 empty 2.22 70.9 13.3 No No
7 empty 2.19 61 15.4 No No
8 empty 2.38 79.7 9.8 No No
9 empty 2.27 60.4 12.6 No No
10 empty 2.24 76.4 12.2 No No
3S8V_B Low-density lipoprotein receptor-related protein 6 Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.13 65.4 46.7 Yes No
2 empty 1.76 73.2 48 No No
3 empty 2.36 69.8 46.1 No No
4 empty 1.67 86.2 31.3 Yes No
5 empty 2.51 72.3 20.8 No No
6 empty 2.45 61.8 17.6 No No
7 empty 2.39 64.8 19.1 No No
8 empty 1.94 65.5 18 No No
9 empty 1.96 60.8 15.8 No No
10 empty 1.78 66.5 11.1 No No
5AIR_B Low-density lipoprotein receptor-related protein 6 Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 2.04 68.8 39.1 Yes Yes
2 empty 2.42 61.2 28.3 No No
3 empty 1.97 59.1 22.3 No No
4 empty 2.14 60.7 26 No No
5 empty 1.9 62 25.7 No No
6 empty 1.89 59.7 18.6 No No
7 empty 2 62.8 12.3 No No
8 empty 1.99 68.4 11.1 No No
9 empty 2.1 61.9 13.7 No No
10 empty 1.89 70.7 16.3 No No
6H15_B Low-density lipoprotein receptor-related protein 6 Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 1.81 70.6 65.4 Yes Yes
2 empty 2.43 62.7 27.7 No No
3 empty 2.55 70.3 31.2 No No
4 empty 1.6 100 0 Yes No
5 empty 2.13 63.5 16.3 No No
6 empty 2.04 65 18.4 No No
7 empty 2.21 59.3 17.2 No No
8 empty 2.58 59.9 19.9 No No
9 empty 2.59 60.3 18.2 No No
10 empty 2.5 74.6 16.8 No No
3SOV_A Low-density lipoprotein receptor-related protein 6 Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.36 65.4 23.9 No No
2 bound 2.27 67 20.8 No No
3 bound 1.99 60.9 23.5 No No
4 empty 2.73 68.7 25.8 No No
5 bound 2.52 77.3 14.5 No No
6 empty 1.36 99.8 0 Yes No
7 empty 1.84 62.1 17.3 No No
8 empty 1.88 66.1 11.5 No No
9 empty 2.34 66.2 12.1 No No
10 empty 2.06 61.2 11.9 No No
3S2K_A Low-density lipoprotein receptor-related protein 6 Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.74 70.4 64.1 Yes Yes
2 empty 2.32 61.2 30.1 No No
3 empty 1.65 78.1 31.4 No No
4 empty 2.35 68 27.9 No No
5 empty 2.23 66.5 24.2 No No
6 empty 2.2 68.4 21.6 No No
7 bound 1.81 64.4 17.2 No No
8 empty 1.81 64.3 13.6 No No
9 empty 2.48 65.5 17.5 No No
10 empty 2.68 59.7 21.1 No No
4A0P_A Low-density lipoprotein receptor-related protein 6 Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 2.08 66.3 43.2 Yes Yes
2 empty 1.71 80.6 28.4 Yes Yes
3 empty 2.26 70.5 22.1 No No
4 empty 1.63 99 0 Yes No
5 empty 2.13 60.7 16.6 No No
6 empty 1.61 64.3 14.2 No No
7 empty 2 60.1 15.3 No No
8 empty 2.26 71.6 12.7 No No
9 empty 1.93 59 11.2 No No
10 empty 2.13 50.9 16 No No
4DG6_A Low-density lipoprotein receptor-related protein 6 Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.04 67 43.7 Yes Yes
2 empty 1.61 86.3 31.6 Yes Yes
3 bound 1.79 77.8 34.9 No No
4 empty 2.18 66.2 27 No No
5 empty 2.07 65 17.9 No No
6 empty 2.38 66.8 17.5 No No
7 empty 2.5 70.3 13.6 No No
8 empty 2.21 60 21.1 No No
9 empty 2 66.3 17.9 No No
10 empty 1.84 66.1 17.5 No No

Domain-based assessment (last updated 30/07/2012)


Domains assessed9
Domains assessed as druggable using the strict criteria4
Domains assessed as druggable using the relaxed criteria6

PDB (Domain) Protein Name Domain Resolution Ligands Druggable Relaxed Druggable Strict
3S8Z_A (4130055) Low-density lipoprotein receptor-related protein 6 6-bladed beta-propeller, YWTD domain, YWTD domain 2.75Å Yes Yes
3S94_B (4229732) Low-density lipoprotein receptor-related protein 6 6-bladed beta-propeller, YWTD domain, YWTD domain 2.8Å Yes Yes
3S94_A (4118060) Low-density lipoprotein receptor-related protein 6 6-bladed beta-propeller, YWTD domain, YWTD domain 2.8Å Yes Yes
3SOB_B (3710361) Low-density lipoprotein receptor-related protein 6 6-bladed beta-propeller, YWTD domain, UNMATCHED 1.9Å Yes No
3SOB_B (3710362) Low-density lipoprotein receptor-related protein 6 PFAM, PFAM, PFAM EGF 1.9Å No No
3SOQ_A (3710378) Low-density lipoprotein receptor-related protein 6 6-bladed beta-propeller, YWTD domain, UNMATCHED 1.9Å Yes No
3SOQ_A (3710379) Low-density lipoprotein receptor-related protein 6 PFAM, PFAM, PFAM EGF 1.9Å No No
3SOV_A (3710385) Low-density lipoprotein receptor-related protein 6 6-bladed beta-propeller, YWTD domain, UNMATCHED 1.27Å No No
4A0P_A (4152935) Low-density lipoprotein receptor-related protein 6 6-bladed beta-propeller, YWTD domain, YWTD domain 1.9Å Yes Yes
Ligand-based Druggability Score: 0.8
Ligand-based Druggability Score Percentile: 88%
Ligand-based Druggability Help: Help




		
Number of proteins in the network : 13346


LRP6 is involved in 20 interactions in the network.


Druggability
Overall Druggability Percentile: 72.05
Druggability for Cancer Therapeutics: 72.69
Druggability for Other Therapeutics: 87.11
Cancer-Associated
Cancer-associated percentile : 82.67
Network Articulation Point
Is LRP6 critical for communication in the network?


Detailed Graph Legend:Help