Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

FKBP6 (O75344) - Overview - Molecular Target Synopsis

Protein


FKBP6, Inactive peptidyl-prolyl cis-trans isomerase FKBP6
UniProt O75344

Also Known as FKBP6_HUMAN, FKBP6, FKBP36

Co-chaperone required during spermatogenesis to repress transposable elements and prevent their mobilization, which is essential for the germline integrity. Acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins and govern the methylation and subsequent repression of transposons. Acts as a co-chaperone via its interaction with HSP90 and is required for the piRNA amplification process, the secondary piRNA biogenesis. May be required together with HSP90 in removal of 16 nucleotide ping-pong by-products from Piwi complexes, possibly facilitating turnover of Piwi complexes. Interacts (via TPR repeats) with HSP90 (By similarity). Interacts with HSP72/HSPA2 and CLTC. Interacts with GAPDH; leading to inhibit GAPDH catalytic activity.

3B7X
CRYSTAL STRUCTURE OF HUMAN FK506-BINDING PROTEIN 6
RCSB/PDB
Inspect Structure
See all 3D Structures for FKBP6

Isoforms / Transcripts (Protein Coding)


Sub-cellular localization


UniProt: FKBP6 is active in the following subcellular-locations: chromosome, cytoplasm, cytosol, nucleus.
GO terms: FKBP6 is active in the following subcellular-locations: cytoplasm, cytosol, synaptonemal complex.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project FKBP6 has gain in 2 cell-lines, loss in 3 cell-lines and no signal in 1000 cell-lines. (see details)

Gene Expression


In NCI60, the highest expressing cell lines are: A498, MCF7, OVCAR_5

In Array Express (RNA-seq of 675 commonly used human cancer cell lines), the highest expressing cell lines are: Hs 746T, NCI-H209, HCC12

In Array Express (RNA-seq of long poly adenylated RNA and long non poly adenylated RNA from ENCODE cell lines), the highest expressing cell lines are: SK-N-SH, NHLF, HSMM

(see details)

3D Structures


For FKBP6 there are:
1 structures (1 chains) solved
0 are solved in complex with at least one small molecule ligand



(see details)
Molecular Target 3D Synopsis

Screening and Chemistry


FKBP6 has been screened with compounds ( bioactivities). (see details)