Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

GUCY1B2 (O75343) - Overview - Molecular Target Synopsis

Protein


GUCY1B2, Guanylate cyclase soluble subunit beta-2
Enzyme Classification 4.6.1.2
UniProt O75343

Also Known as GCYB2_HUMAN, GUCY1B2

Heterodimer of an alpha and a beta chain.

Isoforms / Transcripts (Protein Coding)


Protein Length Ensembl Gene Ensembl Transcript Ensembl Protein Uniprot Isoform
617O75343-1

Drugs


GUCY1B2 is targeted by Approved Drugs Riociguat, Isosorbide Dinitrate. (see details)
Riociguat
Isosorbide Dinitrate

Sub-cellular localization


UniProt: GUCY1B2 is active in the following subcellular-locations: cytoplasm.
GO terms: GUCY1B2 is active in the following subcellular-locations: cytoplasm.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project GUCY1B2 has gain in 0 cell-lines, loss in 0 cell-lines and no signal in 0 cell-lines. (see details)

Gene Expression


In NCI60, the highest expressing cell lines are: MOLT_4, LOXIMVI, SK_MEL_5

In Array Express (RNA-seq of 675 commonly used human cancer cell lines), the highest expressing cell lines are: UACC-812, OVKATE, Hs 746T

In Array Express (RNA-seq of long poly adenylated RNA and long non poly adenylated RNA from ENCODE cell lines), the highest expressing cell lines are: MCF-7, SK-N-SH, NHLF

(see details)

3D Structures


At greater than 50% identity similarity to GUCY1B2 there are:
1 structures (2 chains) solved
0 are solved in complex with at least one small molecule ligand



(see details)
Molecular Target 3D Synopsis

Screening and Chemistry


GUCY1B2 has been screened with 136 compounds (177 bioactivities), 22 compounds have bioactivities that show binding affinity of <= 500nM (27 bioactivities). (see details)