Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

PPFIA4 (O75335) - Overview - Molecular Target Synopsis

Protein


PPFIA4, Liprin-alpha-4
UniProt O75335

Also Known as LIPA4_HUMAN, PPFIA4, KIAA0897

May regulate the disassembly of focal adhesions. May localize receptor-like tyrosine phosphatases type 2A at specific sites on the plasma membrane, possibly regulating their interaction with the extracellular environment and their association with substrates. Forms homodimers and heterodimers with liprins-alpha and liprins-beta. Interacts with the second PTPase domain of PTPRD, PTPRF and PTPRS. Binds RIMS1, RIMS2, GIT1, KIF1A and GRIP1.

Isoforms / Transcripts (Protein Coding)


Sub-cellular localization


UniProt: PPFIA4 is active in the following subcellular-locations: cell surface, cytoplasm.
GO terms: PPFIA4 is active in the following subcellular-locations: cell surface, cytosol, intracellular, presynaptic active zone, synapse.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project PPFIA4 has gain in 2 cell-lines, loss in 0 cell-lines and no signal in 1003 cell-lines. (see details)

Gene Expression


In NCI60, the highest expressing cell lines are: SNB_75, RXF_393, MCF7

In Array Express (RNA-seq of 675 commonly used human cancer cell lines), the highest expressing cell lines are: NCI-H847, CPC-N, NCI-N417

In Array Express (RNA-seq of long poly adenylated RNA and long non poly adenylated RNA from ENCODE cell lines), the highest expressing cell lines are: K562, SK-N-SH, HSMM

(see details)

3D Structures


At greater than 75% identity similarity to PPFIA4 there are:
2 structures (3 chains) solved
0 are solved in complex with at least one small molecule ligand



(see details)
Molecular Target 3D Synopsis