Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

PPFIA3 (O75145) - Overview - Molecular Target Synopsis

Protein


PPFIA3, Liprin-alpha-3
UniProt O75145

Also Known as LIPA3_HUMAN, PPFIA3, KIAA0654

May regulate the disassembly of focal adhesions. May localize receptor-like tyrosine phosphatases type 2A at specific sites on the plasma membrane, possibly regulating their interaction with the extracellular environment and their association with substrates. Forms homodimers and heterodimers with liprins-alpha and liprins-beta (PubMed:9624153). Interacts with the second PTPase domain of PTPRD, PTPRF and PTPRS (PubMed:9624153). Binds RIMS1, RIMS2, RIMS3 and RIMS4.

Isoforms / Transcripts (Protein Coding)


Sub-cellular localization


UniProt: PPFIA3 is active in the following subcellular-locations: acrosome, cytoplasm, cytoplasmic vesicle, secretory vesicle.
GO terms: PPFIA3 is active in the following subcellular-locations: acrosomal vesicle, cytosol, epididymosome, glutamatergic synapse, presynaptic active zone, presynaptic active zone cytoplasmic component.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project PPFIA3 has gain in 2 cell-lines, loss in 2 cell-lines and no signal in 1001 cell-lines. (see details)

Gene Expression


In NCI60, the highest expressing cell lines are: K_562, PC_3, T47D

In Array Express (RNA-seq of 675 commonly used human cancer cell lines), the highest expressing cell lines are: SUM 52PE, NCI-H187, NCI-H1155

In Array Express (RNA-seq of long poly adenylated RNA and long non poly adenylated RNA from ENCODE cell lines), the highest expressing cell lines are: K562, NHLF, HSMM

(see details)

3D Structures


At greater than 75% identity similarity to PPFIA3 there are:
1 structures (1 chains) solved
0 are solved in complex with at least one small molecule ligand



(see details)
Molecular Target 3D Synopsis