PPFIA3 (O75145) - Overview - Molecular Target Synopsis
Also Known as LIPA3_HUMAN, PPFIA3, KIAA0654
May regulate the disassembly of focal adhesions. May localize receptor-like tyrosine phosphatases type 2A at specific sites on the plasma membrane, possibly regulating their interaction with the extracellular environment and their association with substrates. Forms homodimers and heterodimers with liprins-alpha and liprins-beta (PubMed:9624153). Interacts with the second PTPase domain of PTPRD, PTPRF and PTPRS (PubMed:9624153). Binds RIMS1, RIMS2, RIMS3 and RIMS4.
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UniProt: PPFIA3 is active in the following subcellular-locations: acrosome, cytoplasm, cytoplasmic vesicle, secretory vesicle.
GO terms: PPFIA3 is active in the following subcellular-locations: acrosomal vesicle, cytosol, epididymosome, glutamatergic synapse, presynaptic active zone, presynaptic active zone cytoplasmic component.