Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

ABCB7 (O75027) - Overview - Molecular Target Synopsis

Protein


ABCB7, ATP-binding cassette sub-family B member 7, mitochondrial
UniProt O75027

Also Known as ABCB7_HUMAN, ABCB7, ABC7

Could be involved in the transport of heme from the mitochondria to the cytosol. Plays a central role in the maturation of cytosolic iron-sulfur (Fe/S) cluster-containing proteins. Homodimer or heterodimer.

Isoforms / Transcripts (Protein Coding)


Sub-cellular localization


UniProt: ABCB7 is active in the following subcellular-locations: mitochondrion inner membrane.
GO terms: ABCB7 is active in the following subcellular-locations: integral component of membrane, mitochondrial inner membrane.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project ABCB7 has gain in 0 cell-lines, loss in 24 cell-lines and no signal in 981 cell-lines. (see details)

Gene Expression


In NCI60, the highest expressing cell lines are: HL_60, SW_620, NCI_H522

In Array Express (RNA-seq of 675 commonly used human cancer cell lines), the highest expressing cell lines are: RCM-1, OCI-M1, SKM-1

In Array Express (RNA-seq of long poly adenylated RNA and long non poly adenylated RNA from ENCODE cell lines), the highest expressing cell lines are: HeLa-S3, SK-N-SH, NHLF

(see details)

3D Structures


At greater than 50% identity similarity to ABCB7 there are:
6 structures (10 chains) solved
4 are solved in complex with at least one small molecule ligand



(see details)
Molecular Target 3D Synopsis

Screening and Chemistry


ABCB7 has been screened with compounds ( bioactivities). (see details)