Molecular Target Synopsis
Overview
Domains and Structures
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Chemistry
Ligand Efficiency Plot
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Gene Copy Number Variation
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TIM9 (O74700) - Overview - Molecular Target Synopsis

Protein


TIM9, Mitochondrial import inner membrane translocase subunit TIM9
UniProt O74700

Also Known as TIM9_YEAST, TIM9

Mitochondrial intermembrane chaperone that participates in the import and insertion of multi-pass transmembrane proteins into the mitochondrial inner membrane. Also required for the transfer of beta-barrel precursors from the TOM complex to the sorting and assembly machinery (SAM complex) of the outer membrane. Acts as a chaperone-like protein that protects the hydrophobic precursors from aggregation and guide them through the mitochondrial intermembrane space. Compared to TIM10, it may have a strong structural role. Heterohexamer; composed of 3 copies of TIM9 and 3 copies of TIM10, named soluble 70 kDa complex. Associates with the TIM12 component of the TIM22 complex, whose core is composed of TIM18, TIM22 and TIM54. Interacts with the transmembrane regions of multi-pass transmembrane proteins in transit.

3DXR
CRYSTAL STRUCTURE OF THE YEAST INTER-MEMBRANE SPACE CHAPERONE ASSEMBLY TIM9.10
RCSB/PDB
Inspect Structure
See all 3D Structures for TIM9

Isoforms / Transcripts (Protein Coding)


Protein Length Ensembl Gene Ensembl Transcript Ensembl Protein Uniprot Isoform
87O74700-1

Sub-cellular localization


UniProt: TIM9 is active in the following subcellular-locations: mitochondrion inner membrane, mitochondrion intermembrane space.
GO terms: TIM9 is active in the following subcellular-locations: integral component of membrane, mitochondrial intermembrane space, mitochondrial intermembrane space protein transporter complex, mitochondrion, TIM22 mitochondrial import inner membrane insertion complex.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project TIM9 has gain in 0 cell-lines, loss in 0 cell-lines and no signal in 0 cell-lines. (see details)

3D Structures


For TIM9 there are:
1 structures (1 chains) solved
0 are solved in complex with at least one small molecule ligand



(see details)
Molecular Target 3D Synopsis