Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

radA (O74036) - Overview - Molecular Target Synopsis

Protein


radA, DNA repair and recombination protein RadA
UniProt O74036

Also Known as RADA_PYRFU, radA

Involved in DNA repair and in homologous recombination. Binds and assemble on single-stranded DNA to form a nucleoprotein filament. Hydrolyzes ATP in a ssDNA-dependent manner and promotes DNA strand exchange between homologous DNA molecules.

5JFG
STRUCTURE OF HUMANISED RADA-MUTANT HUMRADA22F IN COMPLEX WITH PEPTIDE FHTA
RCSB/PDB
Inspect Structure
See all 3D Structures for radA

Isoforms / Transcripts (Protein Coding)


Protein Length Ensembl Gene Ensembl Transcript Ensembl Protein Uniprot Isoform
349O74036-1

Gene Copy Number Variation


In COSMIC - Cell Lines Project radA has gain in 0 cell-lines, loss in 0 cell-lines and no signal in 0 cell-lines. (see details)

3D Structures


For radA there are:
34 structures (49 chains) solved
14 are solved in complex with at least one small molecule ligand



(see details)
Molecular Target 3D Synopsis

Screening and Chemistry


radA has been screened with compounds ( bioactivities). (see details)