Molecular Target
Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Cellline Data Matrix
Gene Expression
Gene Copy Number Variation
RNA Interference
Mutations

Molecular Target Synopsis - HTR3A (O70212) - Overview

Protein


HTR3A, 5-hydroxytryptamine receptor 3A
UniProt O70212

Also Known as 5HT3A_CAVPO, HTR3A, 5HT3R, HTR3

This is one of the several different receptors for 5-hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. This receptor is a ligand-gated ion channel, which when activated causes fast, depolarizing responses in neurons. It is a cation-specific, but otherwise relatively nonselective, ion channel. Forms pentahomomeric complex as well as pentaheteromeric complex with HTR3B or HTR3C or HTR3D or HTR3E; homomeric complex is functional but exhibits low conductance with modified voltage dependence, and decreased agonist and antagonist affinity. Interacts with RIC3.

Variants and Isoforms


O70212-1, O70212-2

Sub-cellular localization


UniProt: HTR3A is active in the following subcellular-locations: Cell junction, Cell membrane, Postsynaptic cell membrane, Synapse.



UniProt
GO terms

Screening and Chemistry


HTR3A has been screened with 105 compounds (199 bioactivities), 20 compounds have bioactivities that show binding affinity of <= 500nM (21 bioactivities). (see details)