Molecular Target Synopsis
Domains and Structures
Drugs and Clinical Candidates
Ligand Efficiency Plot
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation

HTR3A (O70212) - Overview - Molecular Target Synopsis


HTR3A, 5-hydroxytryptamine receptor 3A
UniProt O70212

Also Known as 5HT3A_CAVPO, HTR3A, 5HT3R, HTR3

This is one of the several different receptors for 5-hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. This receptor is a ligand-gated ion channel, which when activated causes fast, depolarizing responses in neurons. It is a cation-specific, but otherwise relatively nonselective, ion channel. Forms pentahomomeric complex as well as pentaheteromeric complex with HTR3B or HTR3C or HTR3D or HTR3E; homomeric complex is functional but exhibits low conductance with modified voltage dependence, and decreased agonist and antagonist affinity. Interacts with RIC3.

Isoforms / Transcripts (Protein Coding)

Protein Length Ensembl Gene Ensembl Transcript Ensembl Protein Uniprot Isoform

Sub-cellular localization

UniProt: HTR3A is active in the following subcellular-locations: cell junction, cell membrane, postsynaptic cell membrane, synapse.
GO terms: HTR3A is active in the following subcellular-locations: cell junction, integral component of synaptic vesicle membrane, postsynaptic membrane.

GO terms

Gene Copy Number Variation

In COSMIC - Cell Lines Project HTR3A has gain in 0 cell-lines, loss in 0 cell-lines and no signal in 0 cell-lines. (see details)

RNA Interference

HTR3A was reported in the following RNAI studies:

Cell - Large Scale Profiling of Kinase Dependencies in Cancer Cell Lines, the highest RNAi cell lines are: . (see details)

Screening and Chemistry

HTR3A has been screened with 105 compounds (199 bioactivities), 20 compounds have bioactivities that show binding affinity of <= 500nM (21 bioactivities). (see details)