Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Tool Compounds
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Cellline Data Matrix
Gene Expression
Gene Copy Number Variation
RNA Interference
Mutations

HTR3A (O70212) - Overview - Molecular Target Synopsis



Protein


HTR3A, 5-hydroxytryptamine receptor 3A
UniProt O70212

Also Known as 5HT3A_CAVPO, HTR3A, 5HT3R, HTR3

This is one of the several different receptors for 5-hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. This receptor is a ligand-gated ion channel, which when activated causes fast, depolarizing responses in neurons. It is a cation-specific, but otherwise relatively nonselective, ion channel. Forms pentahomomeric complex as well as pentaheteromeric complex with HTR3B or HTR3C or HTR3D or HTR3E; homomeric complex is functional but exhibits low conductance with modified voltage dependence, and decreased agonist and antagonist affinity. Interacts with RIC3.

Isoforms / Transcripts (Protein Coding)


Protein Length Ensembl Gene Ensembl Transcript Ensembl Protein Uniprot Isoform
490O70212-1
484O70212-2

Sequences


>O70212

MVLWLQLALL ALLLPTSLAQ GEVRGKGTAQ AHNSTRPALQ RLSDHLLADY 
RKSVRPVRDW RKPTTVSIDA IVYAILSVDE KNQVLTTYIW YRQFWTDEFL
QWNPEDFDNI TKLSIPTDSI WVPDILINEF VDVGKSPNIP YVYVRHQGEV
QNYKPLQVVT ACSLDIYNFP FDVQNCSLTF TSWLHTIQDI NISLWRLPEK
VKSDKSVFMN QGEWELLGVL TEFLEFSDRE SRGSFAEMKF YVVIRRRPLF
YAVTLLLPSI FLMIVDIVGF YLPPDSGERV SFKITLLLGY SVFLIIVSDT
LPATAIGTPL ISVYFVVCMA LLVISLAETI LIVRLVHKQD LQQPVPLWLR
HLVLERIAGL LCLGEQLTSH RGPATLQATK TDDFSGSTLL PAMGNHCGPL
GGPQDLEKTS RGRGSPPPPP REASLAMCGL LQELASIRHF LEKREETREV
ARDWLRVGSV LDKLLFRVYL LAVLAYSITL VTLWSVWHYA

>O70212-2

MVLWLQLALL ALLLPTSLAQ GEVRGKGTAQ AHNSTRPALQ RLSDHLLADY 
RKSVRPVRDW RKPTTVSIDA IVYAILSVDE KNQVLTTYIW YRQFWTDEFL
QWNPEDFDNI TKLSIPTDSI WVPDILINEF VDVGKSPNIP YVYVRHQGEV
QNYKPLQVVT ACSLDIYNFP FDVQNCSLTF TSWLHTIQDI NISLWRLPEK
VKSDKSVFMN QGEWELLGVL TEFLEFSDRE SRGSFAEMKF YVVIRRRPLF
YAVTLLLPSI FLMIVDIVGF YLPPDSGERV SFKITLLLGY SVFLIIVSDT
LPATAIGTPL ISVYFVVCMA LLVISLAETI LIVRLVHKQD LQQPVPLWLR
HLVLERIAGL LCLGEQLTSH RGPATLQATK TDDFSAMGNH CGPLGGPQDL
EKTSRGRGSP PPPPREASLA MCGLLQELAS IRHFLEKREE TREVARDWLR
VGSVLDKLLF RVYLLAVLAY SITLVTLWSV WHYA

Sub-cellular localization


UniProt: HTR3A is active in the following subcellular-locations: Cell junction, Cell membrane, postsynaptic cell membrane, synapse.
GO terms: HTR3A is active in the following subcellular-locations: cell junction, integral component of synaptic vesicle membrane, postsynaptic membrane.



UniProt
GO terms

Screening and Chemistry


HTR3A has been screened with 105 compounds (199 bioactivities), 20 compounds have bioactivities that show binding affinity of <= 500nM (21 bioactivities). (see details)