Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

murA (O67315) - Overview - Molecular Target Synopsis

Protein


murA, UDP-N-acetylglucosamine 1-carboxyvinyltransferase
Enzyme Classification 2.5.1.7
UniProt O67315

Also Known as MURA_AQUAE, murA

Cell wall formation. Adds enolpyruvyl to UDP-N-acetylglucosamine.

3SWG
AQUIFEX AEOLICUS MURA IN COMPLEX WITH UDP-N-ACETYLMURAMIC ACID AND COVALENT ADDUCT OF PEP WITH CYS124
RCSB/PDB
Inspect Structure
See all 3D Structures for murA

Isoforms / Transcripts (Protein Coding)


Protein Length Ensembl Gene Ensembl Transcript Ensembl Protein Uniprot Isoform
425O67315-1

Sub-cellular localization


UniProt: murA is active in the following subcellular-locations: cytoplasm.
GO terms: murA is active in the following subcellular-locations: cytoplasm.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project murA has gain in 0 cell-lines, loss in 0 cell-lines and no signal in 0 cell-lines. (see details)

3D Structures


For murA there are:
2 structures (2 chains) solved
2 are solved in complex with at least one small molecule ligand



(see details)
Molecular Target 3D Synopsis

Screening and Chemistry


murA has been screened with compounds ( bioactivities). (see details)