Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

kdsB (O66914) - Overview - Molecular Target Synopsis

Protein


kdsB, 3-deoxy-manno-octulosonate cytidylyltransferase
Enzyme Classification 2.7.7.38
UniProt O66914

Also Known as KDSB_AQUAE, kdsB

Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria.

2Y6P
EVIDENCE FOR A TWO-METAL-ION-MECHANISM IN THE KDO-CYTIDYLYLTRANSFERASE KDSB
RCSB/PDB
Inspect Structure
See all 3D Structures for kdsB

Isoforms / Transcripts (Protein Coding)


Protein Length Ensembl Gene Ensembl Transcript Ensembl Protein Uniprot Isoform
234O66914-1

Sub-cellular localization


UniProt: kdsB is active in the following subcellular-locations: cytoplasm.
GO terms: kdsB is active in the following subcellular-locations: cytosol.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project kdsB has gain in 0 cell-lines, loss in 0 cell-lines and no signal in 0 cell-lines. (see details)

3D Structures


For kdsB there are:
1 structures (3 chains) solved
1 are solved in complex with at least one small molecule ligand



(see details)
Molecular Target 3D Synopsis