Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

adk (O66490) - Overview - Molecular Target Synopsis

Protein


adk, Adenylate kinase
Enzyme Classification 2.7.4.3
UniProt O66490

Also Known as KAD_AQUAE, adk

Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism. Monomer.

4CF7
CRYSTAL STRUCTURE OF ADENYLATE KINASE FROM AQUIFEX AEOLICUS WITH MGADP BOUND
RCSB/PDB
Inspect Structure
See all 3D Structures for adk

Isoforms / Transcripts (Protein Coding)


Protein Length Ensembl Gene Ensembl Transcript Ensembl Protein Uniprot Isoform
206O66490-1

Sub-cellular localization


UniProt: adk is active in the following subcellular-locations: cytoplasm.
GO terms: adk is active in the following subcellular-locations: cytoplasm.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project adk has gain in 0 cell-lines, loss in 0 cell-lines and no signal in 0 cell-lines. (see details)

3D Structures


For adk there are:
14 structures (28 chains) solved
13 are solved in complex with at least one small molecule ligand
3 are solved with an approved drug

adk is solved in complex with the approved drug(s):

AMP/ADENOSINE PHOSPHATE (3SR0_A, 3SR0_B, 4CF7_B, 4IKE_A, 4IKE_B).

(see details)
Molecular Target 3D Synopsis

Screening and Chemistry


adk has been screened with compounds ( bioactivities). (see details)