Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

unc-43 (O62305) - Overview - Molecular Target Synopsis

Protein


unc-43, Calcium/calmodulin-dependent protein kinase type II
Enzyme Classification 2.7.11.17
UniProt O62305

Also Known as KCC2D_CAEEL, unc-43

Acts in the signaling of a variety of pathways and processes. Phosphorylates 'Ser-319' of daf-16 in response to stress signals, such as heat, starvation and oxidation, which plays a role in prolonging lifespan. Required for viability under chronic osmotic stress in which it acts downstream of osr-1. Has roles in locomotion, oocyte maturation, brood size, egg laying, defecation, meiotic maturation and neuronal cell fate specification. Required for the regulation of synaptic density and neuromuscular junction morphology. Regulates the synaptic trafficking of glr-1. Bidirectional modulator of neurotransmitter release with negative modulatory effects mainly mediated via slo-1 activation. Involved in activation of ADF neurons and increased tph-1 transcription following exposure to pathogenic bacteria which leads to learned olfactory aversion to the bacteria. Implicated in the muscle regulation of spicule protraction. In conjunction with egl-2 has a role in the suppression of mating behavior under food deprivation to encourage foraging. Involved in restricting str-2 expression to only one of the two AWC neurons. May suppress the functional response to an internal pacemaker, perhaps by modulating the activity of the IP3 receptor. Dodecamer. Subunits are tightly packed around a central ring-shaped scaffold with extensive contacts between the regulatory segment of one kinase and the catalytic domain of another enabling cooperative activation of a subunit by the adjacent molecule (PubMed:16441656, PubMed:20139983). Interacts with and phosphorylates daf-16; the interaction promotes daf-16 nuclear localization. Interacts with egl-2 and tir-1 (PubMed:15625192, PubMed:21145946). Interacts with nsy-1 (PubMed:11336672).

3KL8
CAMKIINTIDE INHIBITOR COMPLEX
RCSB/PDB
Inspect Structure
See all 3D Structures for unc-43

Isoforms / Transcripts (Protein Coding)


Protein Length Ensembl Gene Ensembl Transcript Ensembl Protein Uniprot Isoform
720O62305-1
571O62305-8
533O62305-5
520O62305-7
518O62305-6
482O62305-4
350O62305-9
309O62305-12
302O62305-10
302O62305-11
269O62305-14
230O62305-2
216O62305-15
215O62305-13
137O62305-3

Sub-cellular localization


UniProt: unc-43 is active in the following subcellular-locations: axon, cell projection, cytoplasm, perikaryon.
GO terms: unc-43 is active in the following subcellular-locations: axon cytoplasm, cytoplasm, neuron projection, perikaryon.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project unc-43 has gain in 0 cell-lines, loss in 0 cell-lines and no signal in 0 cell-lines. (see details)

3D Structures


For unc-43 there are:
5 structures (16 chains) solved
0 are solved in complex with at least one small molecule ligand



(see details)
Molecular Target 3D Synopsis

Screening and Chemistry


unc-43 has been screened with compounds ( bioactivities). (see details)