Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

HPGDS (O60760) - Overview - Molecular Target Synopsis

Protein


HPGDS, Hematopoietic prostaglandin D synthase
Enzyme Classification 5.3.99.2
UniProt O60760

Also Known as HPGDS_HUMAN, HPGDS, GSTS, PGDS, PTGDS2

Bifunctional enzyme which catalyzes both the conversion of PGH2 to PGD2, a prostaglandin involved in smooth muscle contraction/relaxation and a potent inhibitor of platelet aggregation, and the conjugation of glutathione with a wide range of aryl halides and organic isothiocyanates. Also exhibits low glutathione-peroxidase activity towards cumene hydroperoxide. Homodimer.

6N4E
HPGDS COMPLEXED WITH A QUINOLINE-3-CARBOXAMIDE
RCSB/PDB
Inspect Structure
See all 3D Structures for HPGDS

Isoforms / Transcripts (Protein Coding)


Protein Length Ensembl Gene Ensembl Transcript Ensembl Protein Uniprot Isoform
199ENSG00000163106ENST00000295256ENSP00000295256O60760-1

Sub-cellular localization


UniProt: HPGDS is active in the following subcellular-locations: cytoplasm.
GO terms: HPGDS is active in the following subcellular-locations: cytoplasm, cytosol.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project HPGDS has gain in 0 cell-lines, loss in 2 cell-lines and no signal in 1003 cell-lines. (see details)

Gene Expression


In NCI60, the highest expressing cell lines are:

In Array Express (RNA-seq of 675 commonly used human cancer cell lines), the highest expressing cell lines are: KG-1, HEL, NCI-H460

In Array Express (RNA-seq of long poly adenylated RNA and long non poly adenylated RNA from ENCODE cell lines), the highest expressing cell lines are: SK-N-SH, NHLF, HSMM

(see details)

3D Structures


For HPGDS there are:
25 structures (87 chains) solved
25 are solved in complex with at least one small molecule ligand



(see details)
Molecular Target 3D Synopsis

Screening and Chemistry


HPGDS has been screened with 249 compounds (369 bioactivities), 96 compounds have bioactivities that show binding affinity of <= 500nM (145 bioactivities). (see details)